Structure of PDB 7obq Chain z Binding Site BS01

Receptor Information

>7obq Chain z (length=62) Species: 9615 (Canis lupus familiaris)

KKKKKKGKLPKNYDPKVTPDPERWLPMRERSYYRGRKKGKKKDQIGKGTQ
GATAGASSELDA

Ligand information

>7obq Chain 1 (length=165)

cuaugccgaucggguguccgcacuaaguucggcaucaauauggugaccuc
ccgggagcgggggaccaccagguugccuaaggaggggugaaccggcccag
gucggaaacggagcaggucaaaacucccgugcugaucaguagugggaucg
cgccugugaauagca

.<.........<<<<<<<<.<<<<<.<.<<<<<<<<<<<.<<<<<..<<<
<<<....>>>>>>..>>>>>.>>>>........<<<<<.....<<<<..<
.<<<....>>>..>.>>>>...>>>>>.>>>>>>>.>..>>>>>>>...>
>>>>>.......>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7obq Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): K555 K556 K558 K559 K561 N565 P572 R576 W577 P579 M580 K600 G601
• Binding residue (residue number reindexed from 1): K2 K3 K5 K6 K8 N12 P19 R23 W24 P26 M27 K47 G48

Gene Ontology

Molecular Function

• GO:0008312 7S RNA binding
• GO:0043022 ribosome binding

Biological Process

• GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005786 signal recognition particle, endoplasmic reticulum targeting
• GO:0005829 cytosol
• GO:0048500 signal recognition particle

External links

• PDB: RCSB:7obq, PDBe:7obq, PDBj:7obq
• PDBsum: 7obq
• PubMed: 34260909
• UniProt: P33731|SRP72_CANLF Signal recognition particle subunit SRP72 (Gene Name=SRP72)