Structure of PDB 6neq Chain z Binding Site BS01

Receptor Information
>6neq Chain z (length=207) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEDTQNEGKKTKKNKTAFSNVGRKISQRVIHLFDEKGNDLGNMHRANVIR
LMDERDLRLVQRNTSTEPAEYQLMTGLQILQERQRLREMEKANPKTGPTL
RKELILSSNIGQHDLDTKTKQIQQWIKKKHLVQITIKKGKNVDVSENEME
EIFHQILQTMPGIATFSSRPQAVQGGKALMCVLRAFSKNEEKAYKETQET
QERDTLN
Ligand information
>6neq Chain A (length=952) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguuuggucccagccuuccuguuaacucuuaauaaacuuacacaugcaa
gcaucuacaccccagugagaaugcccucuagguuauuaaaacuaagagga
gcuggcaucaagcacacacccuguagcucacgacgccuugcuuaaccaca
ccccacgggaaacagcagugacaaaaauuaagccauaaacgaaaguuuga
cuaaguuauauuaauuaggguugguaaaucucgugccagccaccgcgguc
auacgauuaacccaagcuaacaggaguacggcguaaaacguguuaaagca
ccauaccaaauaggguuaaauucuaacuaagcuguaaaaagccaugauua
aaauaaaaauaaaugacgaaagugacccuacaauagccgacgcacuauag
cuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaacac
agauaauuacauaaacaaaauuauucgccagaguacuacuagcaacagcu
uaaaacucaaaggacuuggcggugcuuuauauccuucuagaggagccugu
ucuauaaucgauaaaccccgauaaaccucaccaauucuugcuaauacagu
cuauauaccgccaucuucagcaaacccuaaaaaggaaaaaaaguaagcgu
aauuaugauacauaaaaacguuaggucaagguguaaccuaugaaauggga
agaaaugggcuacauucucuacaccaagagaaucaagcacgaaaguuauu
augaaaccaauaaccaaaggaggauuuagcaguaaacuaagaauagagug
cuuaguugaauuaggccaugaagcacgcacacaccgcccgucacccuccu
caaauagauucagugcaucuaacccuauuuaaacgcacuagcuacaugag
aggagacaagucguaacaagguaagcauacuggaaagugugcuuggauaa
au
.<<.<<.{..[[>>.>>.<<<<<<<.<..<<<<<<<<..<.<<<.<<<..
<......>......<<......<<<<<<<.<<<<.....>>>>.>>>>>.
>>.<<<....<<...<<<...>>>..>>......>>>..<.....>.>>.
<<.....>>.....>>>>>>>.........<<....<<<<....>>>>..
>>...>>.>>>>>>...<<<<<<<<.....(((.....((.>>>))....
...)))..>>>>>..>.>>>>>>>.....<<<((.....<<<<....<..
..........<<<<<<.......<<<.<<.<<<......>>>..>>.>>>
...............<<....>>.>>>>>>......>....>>>>....<
<<<<<...<<...<<<<.........>>>>...>>>>>>>>.........
.<<<<<<.......))...>>>>>>.>>>.<<<.......<<<....>>>
.....>>>...]]..}<<<<<.<<<<<<<...<<..<<<<<..<<<<<<<
<.<.....<<........>>..........<<<.<<<...........<<
.<<<...<<<<<<......<<....<<<....>>>...........>>..
..<<<<.....>>>>......>.>>>...>>.>>>>>....>>>.>>>..
>..>>>>>>>>.....<<<<......>>>>..............<<<<<<
........>>>>>>..........>>>>>.....<<<<<<<.........
>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<...<<<<<
<...<<.....<<<<<....<<......>>....>>>>>...>>.....>
>>>>>....>.>>.........<<<<<<<<<....>>>>>>>>>......
..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6neq Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit.
Resolution3.32 Å
Binding residue
(original residue number in PDB)		A58 E59 D60 Q62 N63 E64 K66 N71 F75 R115 G133 L137 R140 R144 E160 N166 I167 D171 T174
Binding residue
(residue number reindexed from 1)		A1 E2 D3 Q5 N6 E7 K9 N14 F18 R58 G76 L80 R83 R87 E103 N109 I110 D114 T117
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6neq, PDBe:6neq, PDBj:6neq
PDBsum6neq
PubMed30677741
UniProtQ9H2K0|IF3M_HUMAN Translation initiation factor IF-3, mitochondrial (Gene Name=MTIF3)

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