Structure of PDB 8pk0 Chain y Binding Site BS01

Receptor Information
>8pk0 Chain y (length=244) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSLELERVMSSLLDMGFSNAHINELLSVRRGASLQQLLDIISEFILLGLN
PEPVCVVLKKSPQLLKLPIMQMRKRSSYLQKLGLGEGKLKRVLYCCPEIF
TMRQQDINDTVRLLKEKCLFTVQQVTKILHSCPSVLREDLGQLEYKFQYA
YFRMGIKHPDIVKSEYLQYSLTKIKQRHIYLERLGRYQTPDKKGQTQIPN
PLLKDILRVSEAEFLARTACTSVEEFQVFKKLLAREEEESESST
Ligand information
>8pk0 Chain A (length=1423) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccuc
uaaauccccuuguaaauuuaacuguuaguccaaagaggcucuuuggacac
uaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggc
cuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaauccca
aacauauaacugaacuccucacacccaauuggaccaaucuaucacccuau
agaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcaua
agccugcgucagauuaaaacacugaacugacaauuaacagcccaauaucu
acaaucaaccaacaagucauuauuacccucacugucaacccaacacaggc
augcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuua
ccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagagg
caccgccugcuauauauauauauauauauauauauauauauuggcuccac
gaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgug
aggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuua
uuaaugcaaacagaaaccugcauuaaaaauuucgguuggggcgaccucgg
agcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaag
cgaacacucaauugauccaauaacuugaccaacggaacaaguuacccuag
ggacgcaauccuauucuagaguccauaucaacaauaggguuuuggaucag
gacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauua
aaguccuacgugaucugaguucagaccggaguaauccaggucgguuucua
ucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccua
cuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauac
ccaccccacccaagaacaggguu
<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>......>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
....>>.....>>>>>>>>>>..>>>.<<<<<<<<<...>>>>>>>>>..
.<<<......>>>....<<<.<<<...<..............<....<<<
.........>>>....>.......<<<......>>>..............
..........>...>>>>>>........>>>>>>...<<<<<......>>
>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<.
.......<<<<<..............>>>>>......<<<...<<<<...
....................>>>>.......>>>.....<<......>>.
>>>>.....>>>>..<<<<...<<<<<<<<.<<................<
<<<<<..<<<.........>>>...<<<<<<.............>>>>>>
....<<<...<<<<<<..>>>>>>.<<<<<<<..>>>>>>>.>>>....>
>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<..
...>>>>>.......<<..<<<........<<<<<.<<<<<<..<<<<<.
<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<
<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>
>.....>>.........<<<....>>>............>>>>..>>>>>
>>....<<<<<<<<<...<<.......>>...>>>>>>>>><<<<<.<<<
<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>...
..>>>>>..>...>>>>>.....<<<<<<<....>>>.>>>>........
>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...
<<<....>>>.>>>>>......<<<................>>>...>..
.......<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8pk0 Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Resolution3.03 Å
Binding residue
(original residue number in PDB)		R178 Q192 T208 V209 Y256 K260 K279 R295 V296 S297
Binding residue
(residue number reindexed from 1)		R91 Q105 T121 V122 Y169 K173 K192 R208 V209 S210
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0019843 rRNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006364 rRNA processing
GO:0006390 mitochondrial transcription
GO:0006626 protein targeting to mitochondrion
GO:0007507 heart development
GO:0042255 ribosome assembly
GO:0043010 camera-type eye development
GO:0061668 mitochondrial ribosome assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005762 mitochondrial large ribosomal subunit
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8pk0, PDBe:8pk0, PDBj:8pk0
PDBsum8pk0
PubMed38042949
UniProtQ7Z6M4|MTEF4_HUMAN Transcription termination factor 4, mitochondrial (Gene Name=MTERF4)

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