Structure of PDB 8crx Chain y Binding Site BS01

Receptor Information
>8crx Chain y (length=58) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKLKITQIKSGIATKPNHRETLRSLGLKRIGDTVIKEDRPEFRGMVRTV
RHLVTMEE
Ligand information
>8crx Chain a (length=2903) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caaaguuguguagugcgaucgguggaugccuuggcaccaagagccgauga
aggacguugugaccugcgauaagcccuggggaguuggugagcgagcugug
auccggggguguccgaauggggaaaccuggaauguccggaguaguguccg
guggcccugcccugaauguauaggggugugggugguaacgcggggaagug
aaacaucuuaguacccguaggaagagaaaacaagugugauuccgugagua
guggcgagcgaaagcggaggaggcuaaaccgugugugugucagguguugc
augugcgggguugugggggccuugugguucugcugccgcaggauuggcca
gugagaaauguugcgugaaggugaagcgucugggaaggcguaccggagug
ggugagaguccuguaacuguaagcguggcacuggugugggguugccccga
guagcgugggacucguggaauuucgcgugaaucuggcgggaccacccguc
aagccuaaauacuccuuggugaccgauaguggaugaguaccgugagggaa
gggugaaaaguaccccgggaggggagugaaagaguuccugaaaccggucg
caugcaagccgucagagccuguguggugauggcgugccuuuugaagaaug
agccugcgaguuagugaugcguggcgagguuaacccguggugggggaguc
guagcgaaagcgaguccgauaagggcgugagucgcguguucuagacccga
agcggugugaucuauccauggccaggaugaagcgucgguaagacgucgug
gagguccgaacccacuucaguugaaaauggaggggaugaguuguggauag
gggugaaaggccaaucaaacaccgugauagcugguucuccccgaaaugca
uuuaggugcagcguugcgugguucuuguuggagguagagcacuggauggu
cuagggggcuuaucggcuuaccgaaaucagccaaacuccgaaugcuggca
aguguagcguggcagugagacggcgggugauaagcuucgucgucgagagg
gaaacagcccagaucaucagcuaaggccccuaaguggugacucaguggga
aaggauguggaguugcguagacaaccaggagguuggcuuggaagcagcca
uccuugaaagagugcguaauagcucacuggucaagugauuccgcgccgau
aauguagcggggcuuaaguuauccgccgaagcuguggcaaccuguguggu
uggguaggggagcgucgugucaguggugaagcugccgggugacugugugg
uggaguugaugcgagugagaaugcaggcaugaguagcgugugacgggugg
gaaucccguccgccgauuauccaaggguuccagggucaaguuugucugcc
cugggugagucggguccuaaggcgaggccgacaggcguagucgaugggua
accaguugauauucugguaccggcuugucaccgcaagcugcggagggacg
cagugagguagcucauccccggugaugguuguccggggcuaagugugugg
acugucugguagguaaauccgcugggcgugaagguugaggcaugaugggg
agcccaugguugugggugagugagugauccuguacugucgagaaaagcuu
cgugagcgagguggcggguccgcccguacccuaaaccgacacugguggau
agguagaguauaccgaggcgaucgagugaaucguggugaaggaacucggc
aaaaugcccccguaacuuugggauaagggggaccugagcugucgugcacc
cgugcggugugguggcggugaggggcgcagaguccagggggaaacgacug
uuuaccaaaaacacagguccgugcgaagucguaagacgauguauacggac
ugacuccugcccggugcuggaagguuaaggggaacugugaguguaugcgu
agcggugaacuuaagccccaguaaacggcggugguaacuauaaccauccu
aagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggagu
aacgauuucccuacugucuccaccaugaacucggugaaauugcauuacga
guaaagaugcucguuacgcgcagcaggacggaaagaccccgggaccuuua
cuauaguuugguauuggugauugggacgguuuucugauuguucugguuau
cucacuguggaccgugauccgguucaaggacagugccugauggguaguuu
gacuggggcggucgccuccuaaaggguaacggaggcgcccaaagguuccc
ucagccugguugguaaucagguggugaguguaagugcacaagggggcuug
acugugagacugacaggucgagcagggacgaaagucgggacuagugaucu
gacgguggcuuguggaugcgccgucacucaacggauaaaagguaccccgg
ggauaacaggcugaucuugcccgagcgcucauagcgacggcaugguuugg
caccucgaugucggcucgucgcauccuggggcuggagucggucccaaggg
uugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucg
ugagacaguucggucccuauccgcugcgcgcggaggaaucuugagaaggg
cugucuuuaguacgagaggaccgagacggacugaccucuggugugccagu
uguucugccaagagcauggcugguuggcuacgucggguugugauaaccgc
ugaaagcaucuaagcgggaagcacgcuucaagauaaggguucccacagga
guguuccugguaagguccccgagagaugaucggguugauaggccagacgu
ggacgcaucguaagguguggagcugacugguacuaauagaccgaggacuu
uca
..<<<.......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<.....
.<<<<<<....(((.>>>.....<<<<<<<...<<)))....>>......
.>>>>>>>...>>>....<<<....>>>.......<<<<<......>>>>
>..<<<<.<<<<<.........>>>>>..>>>>>>...<<<<<<.....<
<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....
<<.....>>....>>>>>>..<<<....<<<<..................
....>>>>......<<<<<<<<<......<<<<....>>>>.........
.........<<...<....<<<....<<<<......>>>>.((......<
<<.....))>>>...>>>.......>...>>......>>>>>..>>>>..
...<<<<<<<<.........>>>>>>>>.......<<<<..<<<<>>>>.
..>>>......]].>>>>>>>.]]...............<<....>>...
.]].........<<<<....>>>>..................>>>>>>>>
>>>.......<<<<..<<<.....>>>..>>>>...<.<........>.>
.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<.
.<<<<<<<.....<<<<<<<<<..<<<....<<<.<<......>>.>>>.
....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>..
.<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<....<<<<<<<<.....<<<...<<<.<<<<
...<<.<<<<....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>
>>....>>>>>>>.>>..<<<<<<<<<........>>>>>>>>>....<<
<......>>>...<<<<.<<<...<<<(((.....<<<<<<.........
..<<..<<<<<<<<<........<<<<..<<...<<<.........>>>.
..>>.........<<......>>....>>>>....>>>>>>>>>.>>...
........)))......>>>>>>.>>>...>>>>>>><<<<<.....>>>
>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>.>>>>
>....>>>>>>>>>........>>>>>>.......<<....<<<<<<...
....>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>
>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...
<<<<<........>>>>>))<<<.<<..<..<....<<<<<<<<<....<
<<<..<<<..<<<<<.<<<<<<...((((...>>>>>><<..<<<<...<
<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>..
..<<.........>>.....>>>>>...>>>...>>>>.........>>>
>>>.>>>...>..>..>>.>>>>>>>..>>.....<<......>>>>>>>
.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........
......<<<<<...............>>>>>.<<<..<<<<<<<......
............>>>>>>>..>>>.............<<<<<<<<<..<<
<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>
>.<<<<<.<<<..<<<<<<<..<<<..<<<...<<<<<..<<....>>..
.>>>>>...>>>..>>>>>>>>..>>>>><<<<<<.......>>>>>>..
......<...........<<<<<<.....>>>>>>.....>....>>>>>
..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.......((..<<<<
<......))>>>>>..<<<<<<<<.(((.[[......<<<<<<<<<<..<
<<<<.<<<.<<<<<.<<<<<<<<<<<<<..........>>>>>>>>>>>>
>...<<.<<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..
<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<
...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>..
.<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<
<<<<<<.((..>>>>..))>>>>>>>.............>>>>..>>>>>
>.......<<<<.<.<.<<<<<..<<.......>>>..>>>>.>...>>>
>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>
.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<.
...>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..
<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<
<<<<<<))))>>>>>>..>>>>>>..>>>>.>>>>>...<<<....<<<<
<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<
....>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<
....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>......>>
>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8crx Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		K11 S12 I14 A15 P18 N19 R21 E22 T23 R25 S26 K30 I32 K38 P42 E43 F44 G46
Binding residue
(residue number reindexed from 1)		K10 S11 I13 A14 P17 N18 R20 E21 T22 R24 S25 K29 I31 K37 P41 E42 F43 G45
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8crx, PDBe:8crx, PDBj:8crx
PDBsum8crx
PubMed36864821
UniProtA0A2B7I5Y4

[Back to BioLiP]