Structure of PDB 6zxe Chain y Binding Site BS01

Receptor Information

>6zxe Chain y (length=325) Species: 9606 (Homo sapiens)

VVADAGAFLRHAALQDIGKNIYTIREVVTEIRDKATRRRLAVLPYELRFK
EPLPEYVRLVTEFSKKTGDYPSLSATDIQVLALTYQLEAEFVGVSHLKQE
PQKVKVSSSIQHPETPLHISGFHLPGGWITPSNIKQIQQELEVRVGCLTT
DFAMQNVLLQMGLHVLAVNGMLIREARSYILRCHGCFKTTSDMSRVFCSH
CGNKTLKKVSVTVSDDGTLHMHFSRNPKVLNPRGLRYSLPTPKGGKYAIN
PHLTEDQRFPQLRLSQKARQKTNVFAPDYIAGVSPFVENDISSRSATLQV
RDSTLGAGRRRLNPNASRKKFVKKR

Ligand information

>6zxe Chain 2 (length=1645)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucgucguaguuccgaccauaaa
cgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcag
cuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaag
cugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugc
ggcuuaauuugacucaacacgggaaaccucacccggcccggacacggaca
ggauugacagauugauagcucuuucucgauuccgugggugguggugcaug
gccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaac
gagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuua
gagggacaaguggcguucagccacccgagauugagcaauaacaggucugu
gaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucag
cgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauu
cgugauggggaucggggauugcaauuauuccccaugaacgaggaauuccc
aguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguac
gucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgc
cggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuag
aggaaguaaaagucguccguagguccugcggaaggaucauuaacg

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>
>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<..>>>>...>>>>>>>>......
....<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>
>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>
>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<..<<<.<<<
<........<<........>>..........<<<<<.<....<<<<<<..
.....<<..<<........>>..>>.....>>>>>>...<<.<<<..<<<
<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>
....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>
>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>
.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<.....
...........<<<.<<<<....>>>>.>>>..............>>>.>
>............<<<<<..........>>>>>...........>>>>>.
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..
<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<
<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>..
.>>.>>>>...>.>.<<<<<<<<.>>>>>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zxe Structural basis for the final steps of human 40S ribosome maturation.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): H118 T121 K315 R320 R323 S325 T328 G331 G332 K333 Y334 Q348 R350 L351 Q353 S379 R381 S382 R388 G393 G395 R396 R398 N402 S404 R405 K406 K407 F408 V409 K410
• Binding residue (residue number reindexed from 1): H112 T115 K228 R233 R236 S238 T241 G244 G245 K246 Y247 Q261 R263 L264 Q266 S292 R294 S295 R301 G306 G308 R309 R311 N315 S317 R318 K319 K320 F321 V322 K323

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0005515 protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0007601 visual perception
• GO:0030490 maturation of SSU-rRNA
• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005829 cytosol
• GO:0030688 preribosome, small subunit precursor

External links

• PDB: RCSB:6zxe, PDBe:6zxe, PDBj:6zxe
• PDBsum: 6zxe
• PubMed: 33208940
• UniProt: Q9ULX3|NOB1_HUMAN RNA-binding protein NOB1 (Gene Name=NOB1)