Structure of PDB 6h4n Chain y Binding Site BS01

Receptor Information

>6h4n Chain y (length=351) Species: 679895 (Escherichia coli BW25113)

ESFAQLFEESLKEIETRPGSIVRGVVVAIDKDVVLVDAGLKSESAIPAEQ
FKNAQGELEIQVGDEVDVALDAVEDGFGETLLSREKAKRHEAWITLEKAY
EDAETVTGVINGKVKGGFTVELNGIRAFLPGSLVDVRPVRDTLHLEGKEL
EFKVIKLDQKRNNVVVSRRAVIESEDPWVAIAKRYPEGTKLTGRVTNLTD
YGCFVEIEEGVEGLVHVSEMDWTNKNIHPSKVVNVGDVVEVMVLDIDEER
RRISLGLKQCKANPWQQFAETHNKGDRVEGKIKSITDFGIFIGLDGGIDG
LVHLSDISWNVAGEEAVREYKKGDEIAAVVLQVDAERERISLGVKQLAED
P

Ligand information

>6h4n Chain I (length=5)

cuccu

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6h4n Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): N286 Y290 F293 E301 L303 H305 R341 I342 S343
• Binding residue (residue number reindexed from 1): N197 Y201 F204 E212 L214 H216 R252 I253 S254

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0003727 single-stranded RNA binding
• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000028 ribosomal small subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0010501 RNA secondary structure unwinding
• GO:2000766 negative regulation of cytoplasmic translation
• GO:2000767 positive regulation of cytoplasmic translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6h4n, PDBe:6h4n, PDBj:6h4n
• PDBsum: 6h4n
• PubMed: 30177741
• UniProt: P0AG67|RS1_ECOLI Small ribosomal subunit protein bS1 (Gene Name=rpsA)