Structure of PDB 8qsj Chain x Binding Site BS01

Receptor Information
>8qsj Chain x (length=338) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEPKFPAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAW
DHVSAKLEQLSAKDFVNEAISHWELQSWACSPNLRCFTFDRGDISRFPPA
RPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALLQTG
CCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWGELE
GDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAG
LLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFR
RVFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRL
Ligand information
>8qsj Chain A (length=1418) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauaccaagcauaauau
agcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaa
cuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccu
aagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaaga
uuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguc
caagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaa
uccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggaca
cuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguagg
ccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaau
cccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacc
cuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccg
cauaagccugcgucagacacugaacugacaauuaacagcccaauaucuac
aaucaaccaacaagucauuauuacccucacugucaacccaacacaggcau
gcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuacc
ccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggca
ccgccgcuccacgaggguucagcugucucuuacuuuuaaccagugaaauu
gaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccua
uggagcuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguug
gggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuu
caccagucaaagcgaacacucaauugauccaauaacuugaccaacggaac
aaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaac
aauagggcgaccucgauggaucaggacaucccgauggugcagccgcuauu
aaagguucguuuaacgauuaaaguccuacgugaucugaguucagaccgga
guaauccaggucgguuucuaucuacuuaaauuccucccuguacgaaagga
caagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauuc
ucaacuuaguauacccaccccacccaagaacaggguuuauauauauauau
auauauauauauauauau
<<<.......<<<<....................................
.<<....>>.........<.....<<.....>>....>........>>.>
>.............<<....>>..................>>>.......
....<<<.......>>>...<.<........>.>.<<<<<<.........
<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<
<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....
>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<
<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........
>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.
..<<<......>>>....<<<.<<<...<..............<....<<
<.........>>>....>.......<<<......>>>.............
..............>...>>>>>>........>>>>>>...<<<<<....
..>>>>>.........>>>>>><......<<..<<<....>>><<<<..<
<<<........<<<<<........>>>>>......<<<...<<<<.....
..................>>>>.......>>>.....<<......>>.>>
>>.....>>>>..<<<<...<<<<<<<<.<<................<<<
<<<..<<<.........>>>...<<<<<<.............>>>>>>..
..<<.>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>
.....<<<<<........>>>>>.......<<..<<<.<<<.....<<<<
.<<<<<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.
....>>>>..>>>.....>>.........<<<....>>>...........
.>>>>..>>>>>>.......<<<...<<<<<<<...<<.......>>...
>>>>>>>>>.>.....<<<<.<<<<<<..<<.<<<<<<......>>>>>>
...>>.<<<<<.>>>>>.....>>>>>..>...>>>>......<<<<<<<
....>>>.>>>>...>>>..>>>.>>...<<<.<<<..............
...>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.......
.....>>>.............<<<<.......>>>>.<<<<<<..>>>>>
>.<<<<<<<..>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qsj Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K37 P207 S208 K215 H218 R275
Binding residue
(residue number reindexed from 1)		K4 P162 S163 K170 H173 R230
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity
GO:0016428 tRNA (cytidine-5-)-methyltransferase activity
GO:0019843 rRNA binding
Biological Process
GO:0001510 RNA methylation
GO:0006364 rRNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005762 mitochondrial large ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8qsj, PDBe:8qsj, PDBj:8qsj
PDBsum8qsj
PubMed38042949
UniProtQ96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransferase NSUN4 (Gene Name=NSUN4)

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