Structure of PDB 8c3a Chain x Binding Site BS01

Receptor Information

>8c3a Chain x (length=173) Species: 5476 (Candida albicans)

VRYAATPANPAKSASARGSYLRVSFKNTRETAQAINGWKLEKAQKYLDQV
LDHQRAIPFRRYNSSIGRTGQGKEFGVTKARWPAKSVNFVKDLLRNAQAN
AEAKGLDSSKLVISHIQVNHAPKQRRRTYRAHGRINAYQSTPSHIELTLT
EEDEQIRLNSRQRGRLASQKRLT

Ligand information

>8c3a Chain 1 (length=3217)

ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggag
gaauguggcacggcuucugcuguguguuauagccucugacgauacugcca
gccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucu
uaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgag
uguuuggguguaaaacccguacgcguaaugaaagugaacgaagguggggg
cccauuagggugcaccaucgaccgauccugauguguucggauggauuuga
guaagagcauagcuguugggacccgaaagauggugaacuaugccugaaua
gggugaagccagaggaaacucugguggaggcucguagcgguucugacgug
caaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccau
cuaguagcugguuccugccgaaguuucccucaggauagcagaagcucgua
ucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaauga
ccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaa
uugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaa
gcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaa
ugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccgg
acgguggccauggaagucggaauccgcuaaggaguguguaacaacucacc
ggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuua
uacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcgugg
aggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagu
gcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacug
aaguggggaaagguuccaugucaacagcaguuggacauggguuagucgau
ccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaa
ccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuu
cacggcaacguaacugaauguggagacgucggcgugagcccugggaggag
uuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggag
auggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcg
cuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaag
ucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugau
agaauaauguagauaagggaagucggcaaaauagauccguaacuucggga
uaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacg
gacaaggggaaucugacugucuaauuaaaacauagcauugugauggucag
aaagugauguugacacaaugugauuucugcccagugcucugaaugucaaa
gugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacuc
ucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaug
gauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagc
caagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagc
uugacucuaguuugacauugugaaaagacauggaggguguagaauaagug
ggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuua
uucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagccc
ucugggcgauccggguugaagacauugucagguggggaguuuggcugggg
cggcacaucuguuaaacgauaacgcagguguccuaagggggacucaugga
gaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuuga
uuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagu
cccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaac
uggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucg
augucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauu
guucacccacuaauagggaacgugagcuggguuuagaccgucgugagaca
gguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuua
guacgagaggaaccguucauucagauaauugguuuuugcggcugucugau
caggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucu
aagucagaauccaugcuagaacgcgaugauuuugcccugcacauuuuaga
uggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacg
gugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaauguca
acaugcgcggggauaaauccuuugcauacgacuuagauguacaacggagu
auuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcu
cuuguugucugauuugu

.......................<<<<<<.....<......>......>>
>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>
>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]....}..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<..<<<<.
.>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<
<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.
>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>
>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<
<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<
<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.
>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..
<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<....
....>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>
>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...
<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>
>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<....
..>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<....
.>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((....
.<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<
.<<<...<<.........>>...>>>.........<<......>>...>>
>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>.
.>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<
<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..
......>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
<<...<<....<<<....>>>..........<<<<<<....>>>>>>...
...>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<....
.<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<
..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>...
.>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>
>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>
>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<
<<<.....<<<<<<<.<<...............<<<<<............
...>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.
....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....
.<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>
>>........<...........<<<<<.......>>>>>.....>.....
>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[
[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<..............
..............................>>.>...>>>>>>>>>>...
<<<<<.....<<<<..<<<<<......>>>>>..............<<<<
...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<....
.>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<
<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<
<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((.
.((((.>>>>>>))))))))))..........]]]]..}}]]]]......
.<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>....
...<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<...
......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.
>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<...
..............>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}
.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<..........
.>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<....
.<<..........<<<......>>>......>>.......<<<<<<...<
<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............
>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.
<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>
>>.>>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c3a New crystal system to promote screening for new eukaryotic inhibitors
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): V2 R3 Y4 S16 R18 Y21 R23 S25 F26 K27 R30 Q34 K43 Q55 R56 R62 Y63 S65 S66 I67 G68 R69 G71 Q72 K74 E75 T79 K80 R82 W83 P84 A85 K86 R96 N97 A100 N101 Q118 V119 R126 R127 T129 Y130 R131 A132 H133 G134 I136 N137 A138 Y139 Q140 S141 R167 N169 S170 R171 Q172 G174 R175 S178 R181 L182
• Binding residue (residue number reindexed from 1): V1 R2 Y3 S15 R17 Y20 R22 S24 F25 K26 R29 Q33 K42 Q54 R55 R61 Y62 S64 S65 I66 G67 R68 G70 Q71 K73 E74 T78 K79 R81 W82 P83 A84 K85 R95 N96 A99 N100 Q117 V118 R125 R126 T128 Y129 R130 A131 H132 G133 I135 N136 A137 Y138 Q139 S140 R157 N159 S160 R161 Q162 G164 R165 S168 R171 L172

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8c3a, PDBe:8c3a, PDBj:8c3a
• PDBsum: 8c3a
• UniProt: A0A8H6BUG0