Structure of PDB 7wtw Chain x Binding Site BS01

Receptor Information

>7wtw Chain x (length=175) Species: 9606 (Homo sapiens)

EETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCK
ETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLK
GDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMAR
TAICNLILGNPPSKVYGNIRAVASR

Ligand information

>7wtw Chain 2 (length=1586)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgauaccgucguaguuccgaccaua
aacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggc
agcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaa
agcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccu
gcggcuuaauuugcacccggcccgacacggacaggauugacagauugaua
gcucuuucucgauuccgugggugguggugcauggccguuguuggcugguu
aauuccgaugaacgagacucuggcaugcuauucuuagagggacaaguggc
guucagccacccgagauugagcuaacaggucugugaugcccuguccgggg
cugcacgcgcgcuacacugacuggcucagcguguccuacgccggcaggcg
cggguaacccguugaaccccauucgugauggggaucggggauugcaauua
uuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguu
gauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauugg
augguuuagugaggcccucggaucggccccgccggggugcccuggcggag
cgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgagg
uuuccguaggugaaccugcggaaggaucauuaacgg

...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<....>>>>...>>>>>>>>....
......<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>.
.>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....
>>>>....>>>..)))).]]....<<<<<<<<..<<..<<<<<.<<<<.<
<<<<<..........<<<<<.....<<<<<<.......<<.<<<......
..>>>.>>.....>>>>>>......<<<.<<.<<<<<<.<<<...<<<..
....>>>...>>>....<<<...<...<<<....>>>..>.....<<<<<
.....>>>>>........>>>...>>.>>>>..>>..>>>....>>>>>.
..>>.>>>>.>>>.>...<<.<<<........<.<<<.<<<<....>>>>
.>>>....>.........>>>.>>......<.....<<<<<.........
.>>>>>.....>.....>>>>>.....<<<<<<<<<.....>>>>>>>>>
......>>...>>>>>>>>......<<<...<<....<<<<.<<....<<
<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>
.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>
><<<<<<<<<....>>>>>>>>>.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7wtw The nucleoplasmic phase of pre-40S formation prior to nuclear export.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): N83 R84 Y85 T86 P87 K89 L111 K112 R114 H175 S177 R178 I180 G181 R182 G185 K186 G187 G188 L204 G231 P233 P234 S235 K236 Y238 R242
• Binding residue (residue number reindexed from 1): N11 R12 Y13 T14 P15 K17 L39 K40 R42 H103 S105 R106 I108 G109 R110 G113 K114 G115 G116 L132 G159 P161 P162 S163 K164 Y166 R170

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005829 cytosol
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:7wtw, PDBe:7wtw, PDBj:7wtw
• PDBsum: 7wtw
• PubMed: 36321656
• UniProt: Q9NRX1|PNO1_HUMAN RNA-binding protein PNO1 (Gene Name=PNO1)