Structure of PDB 7wtv Chain x Binding Site BS01

Receptor Information
>7wtv Chain x (length=175) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCK
ETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLK
GDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMAR
TAICNLILGNPPSKVYGNIRAVASR
Ligand information
>7wtv Chain 2 (length=1574) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccaauuccagcuc
caauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucu
cucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
cgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuu
uguugguuuucggaacugaggccaugauuaagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
agagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgauaccgucguaguuccgaccauaaacgaugccgac
cggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaa
accaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gacccggcccggacacggacaggauugacagauugauagcucuuucucga
uuccgugggugguggugcauggccguuguuggcugguuaauuccgaugaa
cgagacucuggcaugcuauucuuagagggacaaguggcguucagccaccc
gagauugagcuaacaggucugugaugcccuguccggggcugcacgcgcgc
uacacugacuggcucagcguguccuacgccggcaggcgcggguaacccgu
ugaaccccauucgugauggggaucggggauugcaauuauuccccaugaac
gaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccu
gcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuaguga
ggcccucggaucggccccgccggggugcccuggcggagcgcugagaagac
ggucgaacuugacuaucuagaggaaguaaaagucgagguuuccguaggug
aaccugcggaaggaucauuaacgg
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<<........>>>>.>>
>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...
<<.<<<..>>>>>...<<<<<<.<.......<<...<.......>.<<<<
.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<....
...........>>>>>>>.>>.>....>>....<<<<<<..<...<<<<.
.<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>....
...<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<
<<<<...<...<<<<....>>>>...>>>>>>>>..........<<<.<<
.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..)
)>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>.
.)))).]]....<<<<<<<<..<<..<<<<<..<<<.<<<<<<.......
..<<<<<....<.<<<<<<.......<<.<<<........>>>.>>....
.>>>>>>..>...<<<.<<.<<<<<<.<<<...<<<......>>>...>>
>....<<<...<...<<<....>>>..>.....<<<<<.....>>>>>..
......>>>...>>.>>>>..>>..>>>....>>>>>...>>.>>>>.>>
>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>...
......>>>.>>......<.....<<<<<..........>>>>>.....>
.....>>>>>.....<<<<<<<<<.....>>>>>>>>>......>>...>
>>>>>>>......<<<...<<....<<<<.<<....<<<<<<<<.<<<..
<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.
>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>><<<<<<<<<..
..>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7wtv The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		L111 K112 S113 R114 H175 S177 R178 G181 R182 A184 G185 G187 G188 L204 G231 S235 Y238 R242
Binding residue
(residue number reindexed from 1)		L39 K40 S41 R42 H103 S105 R106 G109 R110 A112 G113 G115 G116 L132 G159 S163 Y166 R170
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0042274 ribosomal small subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0032040 small-subunit processome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wtv, PDBe:7wtv, PDBj:7wtv
PDBsum7wtv
PubMed36321656
UniProtQ9NRX1|PNO1_HUMAN RNA-binding protein PNO1 (Gene Name=PNO1)

[Back to BioLiP]