Structure of PDB 7unr Chain x Binding Site BS01

Receptor Information

>7unr Chain x (length=486) Species: 208964 (Pseudomonas aeruginosa PAO1)

EAVTRAPVVTVMGHVDHGKTSLLDYIRRAKVTQHIGAYHVETERGMVTFL
DTPGHAAFTAMRARGAQATDIVILVVAADDGVMPQTQEAVQHAKAAGVPI
VVAVNKIDKPEANPDNIKNGLAALDVIPEEWGGDAPFVPVSAKLGTGVDE
LLEAVLLQAEVLELKATPSAPGRGVVVESRLDKGRGPVATVLVQDGTLRQ
GDMVLVGINYGRVRAMLDENGKPIKEAGPSIPVEILGLDGTPDAGDEMTV
VADEKKAREVALFRQGKFREVKLARAHAGKLENIFENKKTLNIVLKADVR
GSLEALQGSLSGLGNDEVQVRVVGGGVGGITESDANLALASNAVLFGFNV
RADAGARKIVEAEGLDMRYYNVIYDIIEDVKKALTGMLGSDLRENILGIA
EVRDVFRSPKFGAIAGCMVTEGMVHRNRPIRVLRDDVVIFEGELESLRRF
KDDVAEVRAGMECGIGVKSYNDVKVGDKIEVFEKVE

Ligand information

>7unr Chain a (length=1522)

gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggc
ggacgggugaguaaugccuaggaaucugccugguagugggggauaacguc
cggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggau
cuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggu
gggguaaaggccuaccaaggcgacgauccguaacuggucugagaggauga
ucagucacacuggaacugagacacgguccagacuccuacgggaggcagca
guggggaauauuggacaaugggcgaaagccugauccagccaugccgcgug
ugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggc
aguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccgg
cuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaauc
ggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugug
aaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagag
uacgguagagggugguggaauuuccuguguagcggugaaaugcguagaua
uaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacac
ugaggugcgaaagcguggggagcaaacaggauuagauacccugguagucc
acgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcag
cuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacu
caaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauu
cgaagcaacgcgaagaaccuuaccuggccuugacaugcugagaacuuucc
agagauggauuggugccuucgggaacucagacacaggugcugcauggcug
ucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaa
cccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugc
cggugacaaaccggaggaagguggggaugacgucaagucaucauggcccu
uacggccagggcuacacacgugcuacaauggucgguacaaaggguugcca
agccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgca
gucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucag
aaugucacggugaauacguucccgggccuuguacacaccgcccgucacac
caugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacg
guuaccacggagugauucaugacuggggugaagucguaacaagguagccg
uaggggaaccugcggcuggauc

........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>
......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<
<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<
<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<
<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>..
.>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>
>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<
<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<
<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<((
(...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>
..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.
.....<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<
<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>
>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>
>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<
<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>
>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......
<<........>>..........<<<<<<<......<<<<<<<......<<
<....>>>.......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.
......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....
.<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<
<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>
...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..
.<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<
<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.....
....>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<
<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>
>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<
<<<<....>>>>>>>>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7unr Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): R529 G530 R558
• Binding residue (residue number reindexed from 1): R185 G186 R214

Gene Ontology

Molecular Function

• GO:0003743 translation initiation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006413 translational initiation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7unr, PDBe:7unr, PDBj:7unr
• PDBsum: 7unr
• UniProt: Q9HV55|IF2_PSEAE Translation initiation factor IF-2 (Gene Name=infB)