Structure of PDB 7syv Chain x Binding Site BS01

Receptor Information
>7syv Chain x (length=627) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPVICVLGHVDTG
KTKILDKLRHTHVQDGEAGGITQQIGATNVPLEAINEQTKMIKNFDRENV
RIPGMLIIDTPGHESFSNLRNRGSSLCDIAILVVDIMHGLEPQTIESINL
LKSKKCPFIVALNKIDRLYDWKKSPDSDVAATLKKQKKNTKDEFEERAKA
IIVEFAQQGLNAALFYENKDPRTFVSLVPTSAHTGDGMGSLIYLLVELTQ
TMLSKRLAHCEELRAQVMEVKALPGMGTTIDVILINGRLKEGDTIIVPGV
EGPIVTQIRGLLLPPPMKELRVKNQYEKHKEVEAAQGVKILGKDLEKTLA
GLPLLVAYKEDEIPVLKDELIHELKQTLNAIKLEEKGVYVQASTLGSLEA
LLEFLKTSEVPYAGINIGPVHKKDVMKASVMLEHDPQYAVILAFDVRIER
DAQEMADSLGVRIFSAEIIYHLFDAFTKYRQDYKKQKQEEFKHIAVFPCK
MKILPQYIFNSRDPIVMGVTVEAGQVKQGTPMCVPSKNFVDIGIVTSIEV
NHKQVDVAKKGQEVCVKIEPIPGESPKMFGRHFEATDILVSKISRQSIDA
LKDWFRDEMQKSDWQLIVELKKVFEII
Ligand information
>7syv Chain 2 (length=1680) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucuugcucggcgccggcccgaagcguuuacuuugaaaaaau
uagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaa
uaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaa
gagggacggccgggggcauucguauugcgccgcuagaggugaaauucuug
gaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuuca
uuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucgua
guuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccau
gacccgccgggcagcuuccgggaaaccaaagucuuuggguuccgggggga
guaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccacca
ggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccgg
cccggacacggacaggauugacagauugauagcucuuucucgauuccgug
ggugguggugcauggccguucuuaguugguggagcgauuugucugguuaa
uuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccgg
ucggcguaacuucuuagagggacaaguggcguucagccacccgagauuga
gcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcu
acacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaa
cccguugaaccccauucgugauggggaucggggauugcaauuauucccca
ugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaag
ucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuu
agugaggcccucggaucggccccgccggggugcccuggcggagcgcugag
aagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguu
uccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<.........<<.....<<.<<.....
..>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
...>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....
<<<.<<<<..<<<....>>>...>>>>..>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<....<<<<<..<<..>>.>>>.>>..<<<<<<.<.......
<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>.....
...<.<<.<<<<<<<...............>>>>>>>.>>.>....>>..
..<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>...
...>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>.
..>>>...>>.>....<<<<<.<...<...<<<<.<.....>.>>>>...
>>.>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........
>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<..
....<<<......>>>....>>>..))))..].....<<<<<<<..<<..
<<<<<..<<<.<<<<<<......<<........>>..........<<<<<
......<<<<<<...........<<........>>.........>>>>>>
...<<.<<<...<.<<<<<.....<<<.<<<<<....>>>...<<<....
..>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>
>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>
>.....>>.>>>.....>.>>>>>.......>>>>>...>>.>>>>.>>>
.....<<.<<<........<.......<<<.<<<<....>>>>.>>>...
.>.........>>>.>>......<.....<<<<<..........>>>>>.
....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>
>...>>>>>>>..........<..<<.<..<<<<.<<....<<<<<<<<.
<<<..<<<<.<<...<<<<<..<<<...........>.>>....>>>>>.
..>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<
<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7syv Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		R597 G866 M867 R900 K914 N915 K919 K934 H1012 K1013 K1014 R1041
Binding residue
(residue number reindexed from 1)		R6 G275 M276 R309 K323 N324 K328 K343 H421 K422 K423 R450
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:7syv, PDBe:7syv, PDBj:7syv
PDBsum7syv
PubMed35822879
UniProtG1TRL5

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