Structure of PDB 7qwq Chain x Binding Site BS01

Receptor Information
>7qwq Chain x (length=488) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQL
RENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQN
VIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNA
TKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLF
EEMLQVANAIQPDNIVYVMDASIEQACEAQAKAFKDKVDVASVIVTKLDG
HAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEG
LIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMI
PGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGR
IQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQ
SQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQG
Ligand information
>7qwq Chain 1 (length=167) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuaugccgaucggguguccgcacuaaguucggcaucaauauggugacc
ucccgggagcgggggaccaccagguugccuaaggaggggugaaccggccc
aggucggaaacggagcaggucaaaacucccgugcugaucaguagugggau
cgcgccugugaauagcc
.<<<<.........<..<<<<.<<<<<.<.<<<<<<<<<<<..<<<<..<
<<<<<....>>>>>>..>>>>..>>>>........<<<<<......<..<
.<.<<<....>>>..>.>.>....>>>>>.>>>>>>>.>..>>>>>>>..
.>>...>.....>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qwq Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.
Resolution2.83 Å
Binding residue
(original residue number in PDB)		T377 D380 S381 M382 N383 Q385 R402 R405 G409
Binding residue
(residue number reindexed from 1)		T375 D378 S379 M380 N381 Q383 R400 R403 G407
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019003 GDP binding
GO:0030942 endoplasmic reticulum signal peptide binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0030593 neutrophil chemotaxis
GO:0030851 granulocyte differentiation
GO:0031017 exocrine pancreas development
GO:0045047 protein targeting to ER
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7qwq, PDBe:7qwq, PDBj:7qwq
PDBsum7qwq
PubMed35201867
UniProtP61011|SRP54_HUMAN Signal recognition particle subunit SRP54 (Gene Name=SRP54)

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