Structure of PDB 7pzy Chain x Binding Site BS01 |
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| >7pzy Chain 1 (length=3209)
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ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcg
gaggaauguggcacggcuucugcuguguguuauagccucugacgauacug
ccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaauga
ucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugc
gaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugg
gggcccauuagggugcaccaucgaccgauccugauguguucggauggauu
ugaguaagagcauagcuguugggacccgaaagauggugaacuaugccuga
auagggugaagccagaggaaacucugguggaggcucguagcgguucugac
gugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaac
caucuaguagcugguuccugccgaaguuucccucaggauagcagaagcuc
guaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaa
ugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcu
uaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugg
uaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccg
gaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagc
cggacgguggccauggaagucggaauccgcuaaggaguguguaacaacuc
accggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuac
uuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcg
uggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucu
agugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaga
cugaaguggggaaagguuccaugucaacagcaguuggacauggguuaguc
gauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggc
caaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauu
cuucacggcaacguaacugaauguggagacgucggcgugagcccugggag
gaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccg
gagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggu
gcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugcc
aagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguu
gauagaauaauguagauaagggaagucggcaaaauagauccguaacuucg
ggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgc
gaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugg
uacggacaaggggaaucugacugucuaauuaaaacauagcauugugaugg
ucagaaagugauguugacacaaugugauuucugcccagugcucugaaugu
caaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaug
acucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaug
aauggauuaacgagauucccacugucccuaucuacuaucuagcgaaacca
cagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguu
gagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaa
gcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcga
uccggguugaagacauugucagguggggaguuuggcuggggcggcacauc
uguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaa
ucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagug
ugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaa
uuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuugug
gcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcu
cuuccuaucauaccgaagcagaauucgguaagcguuggauuguucaccca
cuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuu
uacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagag
gaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacg
ccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaa
uccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacg
aauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuu
agcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgc
ggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaag
caguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugu
cugauuugu |
.......................<<<<<<.....<......>......>>
>>>.>.........<<....>>..<<<<<......<<.....>>.....>
>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.
....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<......<.
....>......>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<
<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>
>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>
>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<
..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<
..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>
>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<
<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<.
.......>>>>>>>>....>>>>>>>>>...<<.......>>......>>
>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<
...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<....
.>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<.
.....>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.
....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.
....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<
<<<.<<....<<.........>>....>>.........<<......>>..
.>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>
>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..
<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>
>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<
<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<
<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>
......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.
....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<
<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>
....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.
..>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>
>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>
..<<<<.....<<<<<<<.<<.........<.....<<<<<.........
......>>>>><<.<<<<<<<<<<<..<<<<<.<<.....<<<.<<<..<
..>.>>>.>>>......>>>>>.>>.......>>>>>..>>>>>>.>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<
<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<
.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......
>>>>>>........<...........<<<<<.......>>>>>.....>.
....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>.
...<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{
{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<....
.<<<<..<<<<<......>>>>>..............<<<<...>>>>..
>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<
<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......
>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<......
.>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>
>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<
<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.
<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>
.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}
}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<............
.....>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>
>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...
>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<.....
.....<<<<....>>>>......>>.......<<<<<<...<<<<<<<..
<<<......>>>..>>>>>>>.>>>>>>................>>>.>>
>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<
<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>
..>>>>>.. |
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| PDB | 7pzy E-site drug specificity of the human pathogen Candida albicans ribosome. |
| Resolution | 2.32 Å |
Binding residue
(original residue number in PDB) | V2 R3 Y4 S16 R18 Y21 R23 S25 F26 K27 R30 Q34 K43 R56 R62 Y63 S65 S66 I67 G68 R69 G71 Q72 K74 E75 T79 K80 R82 W83 P84 A85 K86 R96 N97 A100 N101 Q118 V119 R127 T129 Y130 R131 A132 H133 G134 R135 I136 N137 A138 Y139 Q140 S141 R167 N169 S170 R171 Q172 G174 R175 S178 R181 L182 |
Binding residue
(residue number reindexed from 1) | V1 R2 Y3 S15 R17 Y20 R22 S24 F25 K26 R29 Q33 K42 R55 R61 Y62 S64 S65 I66 G67 R68 G70 Q71 K73 E74 T78 K79 R81 W82 P83 A84 K85 R95 N96 A99 N100 Q117 V118 R126 T128 Y129 R130 A131 H132 G133 R134 I135 N136 A137 Y138 Q139 S140 R155 N157 S158 R159 Q160 G162 R163 S166 R169 L170 |
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| Enzyme Commision number |
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