Structure of PDB 7oic Chain x Binding Site BS01

Receptor Information

>7oic Chain x (length=342) Species: 9606 (Homo sapiens)

FPAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAWDHVS
AKLEQLSAKDFVNEAISHWELQSAAPSPASWACSPNLRCFTFDRGDISRF
PPARPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALL
QTGCCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWG
ELEGDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLL
AAGLLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLT
HFRRVFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRLT

Ligand information

>7oic Chain A (length=1383)

gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuaccaaaauaaaguauaggcgauagaaauugacuggcgcaauagaua
uaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacu
aaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaagg
agagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcu
aaaagagcacacccgucuauguagcaaaauagugggaagauuuauaggua
gaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaa
ucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaac
ugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacua
auguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguc
agauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauu
auuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaa
aaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaac
aucaccucuagcaucaccaguauuagaggcaccgccuuggcuccacgagg
guucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaaga
ggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuau
uaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucgga
gcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagc
gaaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggg
auaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacga
ccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguu
cguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagua
auccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu

<<<.......<<<<...............................<....
..>...............<<.....>>..........>>.>>........
.....<<....>>.................>>>...........<<<...
....>>>...<.<........>.>.<<<<<<.........<<<.<<..<<
....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<
.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>.
..<<.......>>......>.>>>>......>.>>..<<<<<<....<<<
<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>...........................
>...>>>>>>........>>>>>>...<<<<<......>>>>>.......
..>>>>>><......<<..<<<....>>><<<<..<<<<........<<<
<<...>>>>>......<<<...<<<<.......................>
>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<..
.<<<<<<<<.<<.........<......<<<<<<..<<<.........>>
>...<<<<<<.............>>>>>>....<<<..>>>....>>.>>
>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<......
..>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<
<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<
<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>
....>>.........<<<....>>>............>>>>..>>>>>>.
......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.
>.......<.<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<
<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<...
.>>>.>>>>....>>..>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>......<<<...........
.....>>>.........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oic A distinct assembly pathway of the human 39S late pre-mitoribosome.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): P207 S208 K215
• Binding residue (residue number reindexed from 1): P165 S166 K173

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008168 methyltransferase activity
• GO:0008173 RNA methyltransferase activity
• GO:0008649 rRNA methyltransferase activity
• GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
• GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity
• GO:0016428 tRNA (cytidine-5-)-methyltransferase activity
• GO:0019843 rRNA binding

Biological Process

• GO:0001510 RNA methylation
• GO:0006364 rRNA processing
• GO:0031167 rRNA methylation
• GO:0032259 methylation
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005762 mitochondrial large ribosomal subunit

External links

• PDB: RCSB:7oic, PDBe:7oic, PDBj:7oic
• PDBsum: 7oic
• PubMed: 34315873
• UniProt: Q96CB9|NSUN4_HUMAN 5-methylcytosine rRNA methyltransferase NSUN4 (Gene Name=NSUN4)