Structure of PDB 7oi6 Chain x Binding Site BS01

Receptor Information
>7oi6 Chain x (length=374) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFADLGLEPRVLHALQEAAPEVVQPTTVQSSTIPSLLRGRHVVCAAETGS
GKTLSYLLPLLQRLLGQPSLDSLPIPAPRGLVLVPSRELAQQVRAVAQPL
GRSLGLLVRDLEGGHGMRRIRLQLSRQPSADVLVATPGALWKALKSRLIS
LEQLSFLVLDEADTLLDESFLELVDYILFNPKAQLVLVGATFPEGVGQLL
NKVASPDAVTTITSSKLHCIMPHVKQTFLRLKGADKVAELVHILKHRDRA
ERTGPSGTVLVFCNSSSTVNWLGYILDDHKIQHLRLQGQMPALMRVGIFQ
SFQKSSRDILLCTDIASRGLDSTGVELVVNYDFPPTLQDYIHRAGRVGRV
GSEVPGTVISFVTHPWDVSLVQKI
Ligand information
>7oi6 Chain A (length=1208) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucgguucggagcagaacccaaccuccgagcaguacaugcu
aagacuucaccagucaaagcgaaccucaauugauccaauaacuugacgga
acaaguuacccuaggggcgcaauccuauucuagaguccauaucaacaaua
ggguuuacgaccucuguuggaucaggacaucccgauggugcagccgcuau
uaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuuauc
uacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuuca
caaagcgccuucuaaaugauaucaucucaacuuaauacccacacccaaga
acaggguu
<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>>.....>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>.....<<<<<<...........>>>>>>..<<.....<<<
..<<<<.....>>>>..>>>....>>.........<<<....>>>.....
...>>>>..>>>>>>>.<<....<<<.<<...<<.......>>...>>.>
>>.....>>..............<<<<<..<<.<<<<<<......>>>>>
>...>>.<<<<<.....>>>>>.....>>>>>................>>
>.>>..<<<.<<<.................>>>.>>><<<<<...<<<..
..>>>.>>>>>.<<<.<............>.>>>........<<<<....
...>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7oi6 A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution5.7 Å
Binding residue
(original residue number in PDB)		S156 S157 P160 S161 G239 L250 D293 E294 S295 A349 F369 L370 R371 L372 I456 V503 L511
Binding residue
(residue number reindexed from 1)		S30 S31 P34 S35 G113 L124 D167 E168 S169 A208 F228 L229 R230 L231 I315 V362 L370
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019843 rRNA binding
Biological Process
GO:0042254 ribosome biogenesis
GO:1902775 mitochondrial large ribosomal subunit assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0035770 ribonucleoprotein granule
GO:0042645 mitochondrial nucleoid

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oi6, PDBe:7oi6, PDBj:7oi6
PDBsum7oi6
PubMed34315873
UniProtQ9NUL7|DDX28_HUMAN Probable ATP-dependent RNA helicase DDX28 (Gene Name=DDX28)

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