Structure of PDB 7of5 Chain x Binding Site BS01

Receptor Information

>7of5 Chain x (length=148) Species: 9606 (Homo sapiens)

DYRRVLVCGGNGGAGASCFHSEPRKEFGGPDGGDGGNGGHVILRVDQQVK
SLSSVLSRYQGFSGEDGGSKNCFGRSGAVLYIRVPVGTLVKEGGRVVADL
SCVGDEYIAALGGAGGKGNRFFLANNNRAPVTCTPGQPGQQRVLHLEL

Ligand information

>7of5 Chain A (length=1389)

gcuaaaccuagccccaaaccccaccuuacuaccaaaccuuagccaaacca
uuuacauaaaguauaggcgauagaaauugauggcgcaauagauauaguac
cgcaagggaaagaugaaaaacaagcauaauauagcaaggacuaaccccua
uaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaa
agcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagc
acacccgucuauguagcaaaauagugggaagauuuauagguagaggcgac
aaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguu
caacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacugu
uaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagag
agaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauua
agaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacucc
ucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuagu
auaaguaacaugaaaacauucuccuccgcauaagccugcgucagcugaca
auuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucac
ugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaa
ggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuag
caucaccaguauuagaggcaccgccuuccuuaaauagggauggcuccacg
aggguucagcugucucuuacuuuuaaccagugaaauugaccugcccguga
agaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauu
uauuaaugcaaacaccugcauuaaaaauuucgguuggggcgaccucggag
cagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcg
aaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggga
uaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgac
cucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguuc
guuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaa
uccaggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<..............................<.....
.>...........<<.....>>.........>>.>>.............<
<....>>...............>>>...........<<<.......>>>.
..<.<........>.>.<<<<<<.........<<<.<<..<<....>>..
.>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>
...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<....
...>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>
><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>
>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<
.<<<...<..............<....<<<.........>>>....>...
....<<<......>>>..........................>...>>>>
>>........>>>>>>...<<<<<......>>>>>.........>>>>>>
.......<<..<<<....>>><<<<..<<<<........<<<<..>>>>.
.....<<<...<<<<.......................>>>>.......>
>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<
<.........<......<<<<<<..<<<.........>>>...<<<<<<.
............>>>>>>....<<<.<<<<.....>>>>..>>>....>>
.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<...
.....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<
<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<
...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>.
...>>.........<<<....>>>............>>>>..>>>>>>..
.....<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>
......<<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<
<<<.....>>>>>.....>>>>>..>...>>>.>>>...<<<<<<<....
>>>.>>>>....>>..>>>.>>...<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>......<<<...........
.....>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of5 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): R76 R77 F92 S94 E95 P96 R97 K98 E99 F100 G102 Q121 S130 S142 K143 N144 C145 F146 R148 S149 N198 R201 A202
• Binding residue (residue number reindexed from 1): R3 R4 F19 S21 E22 P23 R24 K25 E26 F27 G29 Q48 S57 S69 K70 N71 C72 F73 R75 S76 N125 R128 A129

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006417 regulation of translation
• GO:0042254 ribosome biogenesis
• GO:0044065 regulation of respiratory system process
• GO:0070129 regulation of mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005761 mitochondrial ribosome

External links

• PDB: RCSB:7of5, PDBe:7of5, PDBj:7of5
• PDBsum: 7of5
• PubMed: 34135319
• UniProt: Q9H4K7|MTG2_HUMAN Mitochondrial ribosome-associated GTPase 2 (Gene Name=MTG2)