Structure of PDB 7obq Chain x Binding Site BS01

Receptor Information
>7obq Chain x (length=393) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGL
NKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCS
KLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPV
IIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVY
VMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSP
IIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLEALIEKLKHGQFTLRD
MYEQFQNIMKMGPFSQILGNEQESMARLKKLMTIMDSMNDQELDSTDGAK
VFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGI
Ligand information
>7obq Chain 1 (length=165) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuaugccgaucggguguccgcacuaaguucggcaucaauauggugaccuc
ccgggagcgggggaccaccagguugccuaaggaggggugaaccggcccag
gucggaaacggagcaggucaaaacucccgugcugaucaguagugggaucg
cgccugugaauagca
.<.........<<<<<<<<.<<<<<.<.<<<<<<<<<<<.<<<<<..<<<
<<<....>>>>>>..>>>>>.>>>>........<<<<<.....<<<<..<
.<<<....>>>..>.>>>>...>>>>>.>>>>>>>.>..>>>>>>>...>
>>>>>.......>..
Receptor-Ligand Complex Structure
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PDB7obq Molecular mechanism of cargo recognition and handover by the mammalian signal recognition particle.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S381 M382 N383 D384 Q399 G401 R402 R405 G409
Binding residue
(residue number reindexed from 1)		S337 M338 N339 D340 Q355 G357 R358 R361 G365
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019003 GDP binding
GO:0030942 endoplasmic reticulum signal peptide binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0030593 neutrophil chemotaxis
GO:0030851 granulocyte differentiation
GO:0031017 exocrine pancreas development
GO:0045047 protein targeting to ER
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7obq, PDBe:7obq, PDBj:7obq
PDBsum7obq
PubMed34260909
UniProtP61010|SRP54_CANLF Signal recognition particle subunit SRP54 (Gene Name=SRP54)

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