Structure of PDB 6htq Chain x Binding Site BS01

Receptor Information
>6htq Chain x (length=341) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDMVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLD
HKLRTGDIVEILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENV
EKGRELVEKEIKNLDFELKDVLTPENIQKVADKFNFSNEEDMYAAVGYNG
ITALQVANRLTEKERKQRDQEEQEKIVQEVTGEPKPYPQGRKREAGVRVK
GIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVHREDCPNVKTNEAQERL
IPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNETKTNISSVS
GKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRR
Ligand information
>6htq Chain A (length=2887) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaug
aaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuug
auccggagauuuccgaauggggaaacccaccacucguaauggagugguau
ccauaucugaauucauaggauaugagaaggcagacccggggaacugaaac
aucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcgg
cgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguugu
aggacacucgaacgagguagaugaagaggucuggaaaggcccgccauagg
agguaacagcccuguagucaaaacuucguucgaguggauccugaguacgg
cggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcu
aaauacucccuagugaccgauagugaaccaguaccgugagggaaagguga
aaagcaccccggaaggggagugaaagagauccugaaaccgugugccuaca
aguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaac
cggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcag
cgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaa
ccaggugaucuacccauguccagggugaaguucagguaacacugaaugga
ggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggg
gugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuu
uagggcuagccucaagguaagagucuuggagguagagcacugauuggacu
aggggccccuaccggguuaccgaauucagucaaacuccgaaugccaauga
cuuauccuugggagucagacugcgagugauaagauccguagucgaaaggg
aaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaa
aggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccac
cauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaa
auguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagug
guaggagagcguucuaagggcugugaagccagaccggaaggacuggugga
gcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaau
ccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucagg
guuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacag
guugauauuccuguaccaccuccucaccauuugagcaauggggggacgca
ggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggc
ugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcg
cgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagag
gugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggu
gaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuuc
gggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaa
uaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaa
ggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggag
cgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccg
uaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccga
cccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucgg
ugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaa
gaccccguggagcuuuacugcagccugauauugaauguugguacagcuug
uacaggauagguaggagccuuggaaaccggagcgccagcuucgguggagg
caucggugggauacuacccuggcuguauugaccuucuaacccgccgcccu
uaucgggcggggagacagugucaggugggcaguuugacuggggcggucgc
cuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaa
aucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuaca
agucgagcagggacgaaagucgggcuuagugauccggugguuccgcaugg
aagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuau
cucccccaagaguccacaucgacggggagguuuggcaccucgaugucggc
ucaucgcauccuggggcuguagucggucccaaggguugggcuguucgccc
auuaaagcgguacgcgagcuggguucagaacgucgugagacaguucgguc
ccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacga
gaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggc
aucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagc
augaagccccccucaagaugagauuucccauuccgcaaggaaguaagauc
ccugaaagaugaucagguugauaggucugagguggaaguguggcgacaca
uggagcugacagauacuaaucgaucgaggacuuaacc
<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<....
..<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<
<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<....
..>......>>>>>.>.........<<....>>...<<<<......<<..
...>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......
<<<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......
<<<.....))>>>...>>>...>>>>>>>>..>>>>..>>>>........
..<<<.........>>>...........<<<<<..<<<<>>>>>..))).
.....]].>>>>>>>.]]...............<<....>>....]]...
......<<<<....>>>>.............}....>>>>>>>>>>>...
....<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<
<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<
<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<
<<<<<<.....<<<<<<.<...<<<....<<<<<<......>>>>>>...
..>>>...<<<.<<<<<........>>>>>>>>.....>.>>>>>>...<
<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<.
...>>>>><<<<<<<<<...<<<<<<<<......<<<...<<<<<<<<..
.<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>......>>>.>>
>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<
......>>>...<<<<.<<<...<<<(((.....<<<<<<..........
.<<..<<<<<<<<<......<.<<<<<.<<...<<...........>>..
.>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>....
.......))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>.
...>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>...
.>.>>>>>>>..>.....>>>>>><......<.....<<<<<<.......
>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>
....((<<<<.<<...<<<................>>>...>>....<<<
<........>>>>.))<<<<..<<<<<<......<<...<<<<....<<.
<<.<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<
<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..
>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>.>
>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>
>...<<<....<<<<<<<<..<<..............<<<<<........
.......>>>>><<<<<....<<<<....>>>>...>>>>>.........
...<<<<<<<<<..<<<.........>>>..<<<<<<<............
..........>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<
<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<
<.......>>>>>>........<...........<<<<<.......>>>>
>.....>....>>>>...>>.>>>>>>>....>>..>>>>>>>>.>>>..
>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[...
...<<<<.[[<<<<..<<<<<.<<<<<<....<<<.<<<<<<<<<<....
..........<<....<<<......<<<<<<<<....>>>>>>>>...>>
>..............>>.....>>>>>>>>>>.>>>....<<.<<<<<..
.....>>>>>>>........>>>>>>..>>>>>..<<<<.....>>>><<
<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<......
.>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<.....
.>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>
..))>>>>>>>.............>>>>..]]>>>>.......<<<<...
<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<
...<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>
>.....>>>>.......>>>..>....<<<<<<<....>>>.>>>>....
]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<........
.......>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>
>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>
>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<
<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>
>...>>>..>>>>>.>>>...>>>>....>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6htq Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel.
Resolution4.5 Å
Binding residue
(original residue number in PDB)
R598 K601 C602 K617 R619 H624 N630 T633
Binding residue
(residue number reindexed from 1)
R208 K211 C212 K227 R229 H234 N240 T243
Enzymatic activity
Enzyme Commision number 2.7.6.5: GTP diphosphokinase.
External links
PDB RCSB:6htq, PDBe:6htq, PDBj:6htq
PDBsum6htq
PubMed32937119
UniProtO54408|RELA_BACSU GTP pyrophosphokinase (Gene Name=relA)

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