Structure of PDB 6g18 Chain x Binding Site BS01

Receptor Information

>6g18 Chain x (length=178) Species: 9606 (Homo sapiens)

EETRKIPVPANRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCK
ETKDVSALTKAADFVKAFILGFQVEDALALIRLDDLFLESFEITDVKPLK
GDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVKVHILGSFQNIKMAR
TAICNLILGNPPSKVYGNIRAVASRSAD

Ligand information

>6g18 Chain 2 (length=1658)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucagauaccgucguaguuccga
ccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgc
cgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguauggu
ugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggcuuaauuugacucaacacgggaaaccucacccggcccggac
acggacaggauugacagauugauagcucuuucucgauuccguggguggug
gugcauggccguucuaguugguggagcgauuugucugguuaauuccgaua
acgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaac
uucuuagagggacaaguggcguucagccacccgagauugagcaauaacag
gucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacug
gcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauu
cgugauggggaucggggauugcaauuauuccccaugaacgaggaauuccc
aguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguac
accgcgucgcuacuaccgauuggaugguuuagugaggcccucggaucggc
cccgccggggugcccuggcggagcgcugagaagacggucgaacuugacua
ucuagaggaaguaaaagucggguuuccguaggugaaccugcggaaggauc
auuaacgg

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((....<.<<<<.....<<..))>>..
.....>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>
>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>
>>.>..>>>...<<.)).>>...>>.....>>>.>.>.<<<......<<<
<....>>>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<..
<<<.<<<<<<............................<<<<<.<....<
<<<<<.......<<.<<<........>>>.>>.....>>>>>>......<
<<<<<<<<<<<<<...<<<.<<<<<....>>>...<<<......>>>...
>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>
>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>
>>>.>>>.>>>>.......>.>>>>>...>>.>>>>.>>>.....<<.<<
<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>
>......<.....<<<<<..........>>>>>.....>.....>>>>>.
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..
<<<.<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<
<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>
>>>...>>.>>>>...>.>>>>><<<<<<<<<....>>>>>>>>>.....
........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g18 Visualizing late states of human 40S ribosomal subunit maturation.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): N83 R84 Y85 T86 P87 L111 H175 R178 I180 R182 A184 G187 G188 L204 G231 P233 K236 R242
• Binding residue (residue number reindexed from 1): N11 R12 Y13 T14 P15 L39 H103 R106 I108 R110 A112 G115 G116 L132 G159 P161 K164 R170

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0005515 protein binding

Biological Process

• GO:0042274 ribosomal small subunit biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005829 cytosol
• GO:0032040 small-subunit processome

External links

• PDB: RCSB:6g18, PDBe:6g18, PDBj:6g18
• PDBsum: 6g18
• PubMed: 29875412
• UniProt: Q9NRX1|PNO1_HUMAN RNA-binding protein PNO1 (Gene Name=PNO1)