Structure of PDB 6frk Chain x Binding Site BS01

Receptor Information
>6frk Chain x (length=374) Species: 9615 (Canis lupus familiaris) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDNKRKMIQHAVFK
ELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWK
TCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKN
ENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEA
QAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDD
FEPFKTQPFISKLLGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFM
SKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGS
GVSTRDVQELLTQYTKFAQMVKKM
Ligand information
>6frk Chain 1 (length=258) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccgggcgcgguggcgcgcgccuguagucccagcuacucgggaggcugag
gcaggaggaucgcuucagugcgcuaugccgaucggguguccgcacuaagu
ucggcaucaauauggugaccucccgggagcgggggaccaccagguugccu
aaggaggggugaaccggcccaggucggaaacggagcaggucaaaacuccc
gugcugaucaguagugggaucgcgccugugaauagccacuguagcgagac
cccgucuc
<<<<<<<<<<..(((.>>>>>>>....<<<<.)))....>>>>>>>.<<<
<<.<<....<<<<<.<<<<<.<<<<........<....<<<.<<<<....
<<<<<<<<<<<.<<<<<..<<<<<<....>>>>>>..>>>>>.>>>>...
.....<<<<<......<<<....<<<....>>>....>>>....>>>>>.
>>>>>>>.....>>>>>>...>....>.....>>>>>>>>>.>>>>>...
>>.>>>>>
Receptor-Ligand Complex Structure
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PDB6frk Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		N70 T377 D380 S381 M382 N383 Q399 R402 R405 G409 S410 G411
Binding residue
(residue number reindexed from 1)		N39 T317 D320 S321 M322 N323 Q339 R342 R345 G349 S350 G351
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019003 GDP binding
GO:0030942 endoplasmic reticulum signal peptide binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0030593 neutrophil chemotaxis
GO:0030851 granulocyte differentiation
GO:0031017 exocrine pancreas development
GO:0045047 protein targeting to ER
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6frk, PDBe:6frk, PDBj:6frk
PDBsum6frk
PubMed29567807
UniProtP61010|SRP54_CANLF Signal recognition particle subunit SRP54 (Gene Name=SRP54)

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