Structure of PDB 8wi9 Chain w Binding Site BS01

Receptor Information
>8wi9 Chain w (length=255) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVDVSTDGELPGAAEYAREKIGRLSRRAHRPVLHARVRLTRHGDPAVER
PVIAQANLDVNGRQVRAQVEGVNAREAVDRLEARLRSRLERIAEHWEARR
GGVPAEAGREWRHESEPARRPGYFPRPPEERRIIRRKSFSMVPCTVDEAA
LEMEMLDYDFHLFTEKGTGFAAVLYKGGPTGYRLVLVIPVPADELSPFEK
PITISTHPAPCLTQRDAVERLGLLGLPFLFYIDAAEGRASVIYRRYDGHY
GLITP
Ligand information
>8wi9 Chain a (length=1515) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacac
augcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgg
gugaguaacacgugggugaucugcccugcacuuugggauaagccugggaa
acugggucuaauaccgaauacacccugcuggucgcauggccugguagggg
aaagcuuuugcggugugggaugggcccgcggccuaucagcuuguuggugg
ggugauggccuaccaaggcgacgacggguagccggccugagagggugacc
ggccacacugggacugagauacggcccagacuccuacgggaggcagcagu
ggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugag
ggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaa
gugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgc
gguaauacguaggguccgagcguuguccggaauuacugggcguaaagagc
ucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugg
gcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauu
ccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcga
aggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggag
cgaacaggauuagauacccugguaguccacgccguaaacgguggguacua
gguguggguuuccuuccuugggauccgugccguagcuaacgcauuaagua
ccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgg
gggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaag
aaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguuc
ccuuguggccugugugcagguggugcauggcugucgucagcucgugucgu
gagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugc
cagcacguuaugguggggacucgugagagacugccggggucaacucggag
gaagguggggaugacgucaagucaucaugccccuuauguccagggcuuca
cacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagc
gaauccuuucaaagccggucucaguucggaucggggucugcaacucgacc
ccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaa
uacguucccgggccuuguacacaccgcccgucacgucaugaaagucggua
acacccgaagccgguggccuaacccuuguggagggagccgucgaaggugg
gaucggcgauugggacgaagucguaacaagguagccguaccggaaggugc
ggcuggaucaccucc
....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<
.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......
<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<...
.>>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>.
...<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<
<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>
>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>
>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<
<......<<<<....>>>>.....>>>>...<.<<<<<......<<....
>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>
.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<
<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>
>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<
<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<..
..>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..
<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>
>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.
<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>...
.......<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<
<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<..
..>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<
<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>..
......>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.
>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>
....>>>......>>>>>>>......<....<<<<<<<........>>>>
>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>...
...>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<.
.<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>.
.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>
>>>>...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wi9 Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		S6 K21 R27 R28 H30 R37 R39 D45 A47 Q55 G62 R66 R75 E76 D79 R80 R84 R91 W96 E97 A98 R100 G101 E110 W111 R112 H113 E114 A118 P121 Y123 F124 P125 Y246 D247
Binding residue
(residue number reindexed from 1)		S6 K21 R27 R28 H30 R37 R39 D45 A47 Q55 G62 R66 R75 E76 D79 R80 R84 R91 W96 E97 A98 R100 G101 E110 W111 R112 H113 E114 A118 P121 Y123 F124 P125 Y246 D247
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0043024 ribosomal small subunit binding
Biological Process
GO:0006417 regulation of translation
GO:0044238 primary metabolic process
GO:0045900 negative regulation of translational elongation
Cellular Component
GO:0022627 cytosolic small ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8wi9, PDBe:8wi9, PDBj:8wi9
PDBsum8wi9
PubMed38245551
UniProtA0QZ86

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