Structure of PDB 8oz0 Chain w Binding Site BS01

Receptor Information
>8oz0 Chain w (length=103) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTR
KTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTI
ADA
Ligand information
>8oz0 Chain W (length=1716) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgccuacuuggauaacuguggu
aauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggg
gaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgca
cgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuu
cgaugguagucgccgugccuaccauggugaccacgggugacggggaauca
ggguucgauuccggagagggagccugagaaacggcuaccacauccaagga
aggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacg
aaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucc
acuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagc
agccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguua
aaaagcucguaguuggaucuugggagcggccccgccccucucggcggccc
gaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgc
cuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuugu
ugguuuucggaacugaggccaugauuaagagggacggccgggggcauucg
uauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccaga
gcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucgga
gguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccg
accggcgaugcggcggcguuauucccaugacccgccgggcagcuuccggg
aaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacu
uaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaau
uugacucaacacgggaaaccucacccggcccggacacggacaggauugac
agauugauagcucuuucucgauuccgugggugguggugcauggccguucu
uaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucu
ggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuu
cuuaagggacaaguggcguucagccacccgagauugagcaauaacagguc
ugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcu
cagcgugugccuacccuacgccggcaggcgcggguaacccguugaacccc
auucgugauggggaucggggauugcaauuauuccccaugaacgaggaauu
cccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuug
uacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucg
gaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacu
ugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaacc
ugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<...<....<.....<<..........>>....>.>.......<<...
.....<<<.<....<<...<.<<<<...........<<.....<<.<<..
.....>>.>>......>>.........<<<<...<<<<........>>>>
...>>>><<..<<<<<.............>>>>>......>>....<<<.
.<<<......>>>.>>>..>>>>.>...>>..>.>>>.<<<....<<<..
..<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<..
..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>
.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>
>.>.....<..<<<<<<............>>.>>>>...>......<<..
<...........>..>>.........<<<<<((....<.<<<<.....<<
..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.
....<.<<...<<<.<<.....<<..........>>.<<...........
..>>...<<<<<<.<.......<<...<.......>.<<<<.......>>
>>...>>......>.>>>..>>>........<.<<.<<<..<<.......
........>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<
..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......
<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<
<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.
<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<.
.))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>
>..)))).]<<<...<<<<<<<..<<..<<<<<..<<<.<<<<<<.....
.<<........>>..........<<<<<......<<<<<<.......<<.
<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<..
..<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<.
......<<<<...<<<<<<<<<<<.......>>>>.>>>>.....>>>..
.>>>.>......<<<<<.....>>>>>........>>>....>>>.>>>.
....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<..<<..
......<.......<<<.<<<<....>>>>.>>>....>.........>>
..>>......<.....<<<<<..........>>>>>.....>.....>>>
>>.....<<<<<<<<.......>>>>>>>>......>>...>>.>>>>>.
>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<.
..<<<<<.......................>>>>>...>>.>>>>..>>>
.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>
>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oz0 The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R19 R21 K51 P53 R55 M56 P57 T58 T64 K67 T68 P69 C70 G71 E72 W77 K86 L88 D90
Binding residue
(residue number reindexed from 1)		R3 R5 K35 P37 R39 M40 P41 T42 T48 K51 T52 P53 C54 G55 E56 W61 K70 L72 D74
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8oz0, PDBe:8oz0, PDBj:8oz0
PDBsum8oz0
PubMed38287194
UniProtP60866|RS20_HUMAN Small ribosomal subunit protein uS10 (Gene Name=RPS20)

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