Structure of PDB 8i0p Chain w Binding Site BS01

Receptor Information
>8i0p Chain w (length=434) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRY
MEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPN
EICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYI
NLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRV
KPLQDQNELFGKIQAEFEKKWENGTFPGWEERAQRLFSTKGKSLESLDTS
LFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQ
ARTGEEREEEEEEKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYR
GPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKA
SERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL
Ligand information
>8i0p Chain G (length=63) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cuccgaacgguaagagccuagcauguagaaugaugucauacuuauccugu
cccuuuuuuuucc
..................................................
.............
Receptor-Ligand Complex Structure
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PDB8i0p Molecular Basis for the activation of Human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		W395 L396
Binding residue
(residue number reindexed from 1)		W328 L329
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtQ12874|SF3A3_HUMAN Splicing factor 3A subunit 3 (Gene Name=SF3A3)

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