Structure of PDB 7naf Chain w Binding Site BS01

Receptor Information
>7naf Chain w (length=361) Species: 1247190 (Saccharomyces cerevisiae BY4741) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGKTQKKNSKGRLDRYYYLAKEKGYRARSSFKIIQINEKYGHFLEKSKVV
IDLCAAPGSWCQVASKLCPVNSLIIGVDIVPMKPMPNVITFQSDITTEDC
RSKLRGYMKTWKADTVLHDGAPNVGLGWVQDAFTQSQLTLQALKLAVENL
VVNGTFVTKIFRSKDYNKLIWVFQQLFEKVEATKPPASRNVSAEIFVVCK
GFKAPKRLDPRLLDPKEVFEELPDGQQNMESKIYNPEKKVRKRQGYEEGD
NLLYHETSILDFVRTEDPISMLGEMNKFTIDENDHEWKILKKLKQTTDEF
RSCIEDLKVLGKKDFKMILRWRKIAREILGLQEKQRLNVKRERRRKNEMK
QKELQRMQMNM
Ligand information
>7naf Chain 1 (length=378) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagggugaagccagaggaaacucugguggaggcucgaaaauggaauuag
acugaaggucggcgcccuggaguuaucuuuucuuguuuaucccgcuucgg
ccccaaggugaacagccucuaauguagauaagggaagucgggggaaucug
acuguuaacgagauucccacugucccuaucuacucggggaacuggcuugu
cggcucuuccuaucauaccauucgguaagcguuggauuguucacccacua
auagggaacgugagcugaauugaacuuaggaacaguucauucggauaauu
gguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgaau
cuauauauuguaagcugagauuaagccu
...<<<....<<<<<<<....>>>>>>>.....>>>..............
.......<<<<........<<<..(((..>>>...............>>>
>....<<<<.....>>>>.....<<<<<<<.<<........<<<<<<<<<
........>>.>>>>>>>.....>>.>>>>>>>.................
.......<<<<..<.<<<......>>>...>.<<<.........>>>...
..>>>>............<.<<<<<<.......>>>>>>.><<<<<...<
<<<....<<<<<<<<<<))).>>>>>..>>>>>...>>>>..>>>>>...
......<<<.........>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7naf Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Resolution3.13 Å
Binding residue
(original residue number in PDB)		M1 G2 K3 T4 K6 K7 S9 R12 Y17 K21 A27 R28 S29 K32 A121 P122 N123 V124 G125 W128 K159 F161 R162 S163 T183 K184 R189 N190 V191 S192 A193 E194 V240 R241 R243 K368 R372 R373 R384
Binding residue
(residue number reindexed from 1)		M1 G2 K3 T4 K6 K7 S9 R12 Y17 K21 A27 R28 S29 K32 A121 P122 N123 V124 G125 W128 K159 F161 R162 S163 T183 K184 R189 N190 V191 S192 A193 E194 V240 R241 R243 K340 R344 R345 R356
Enzymatic activity
Enzyme Commision number 2.1.1.167: 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7naf, PDBe:7naf, PDBj:7naf
PDBsum7naf
PubMed36482249
UniProtP25582|SPB1_YEAST 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase (Gene Name=SPB1)

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