Structure of PDB 7ase Chain w Binding Site BS01

Receptor Information
>7ase Chain w (length=147) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QKRDIVYADPQEGEEYAQVKKALGNLRLELQLADGSKAIGSIRGAMVRKV
WIGQGDVVLVSKRSFNKNDIVDVIHRYNPAEVRALVKDEVIPRDFRSSDE
RDAKNAHSDYVFVAENDDDGGADDDDQNVLDRNKVVLDDPLATFDEL
Ligand information
>7ase Chain 0 (length=2150) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgcaaaaaucuugcggucuccgcaacauuggau
aacuuggcgaaacgccaagcuaauacaugaaccaaccggauguucucugu
uccggcggcagggcaaccugcugccaugggacguccagcgaaugaaugaa
aguaaaaccaaugccuucaccggcaguaacacucagaaguguugauucaa
uucauuccgugcgaaagccggguuuuuuuauccggcgucuuuugacgaac
aacugcccuaucagccagcgauggccguguaguggacugccauggcguug
acgggagcgggggauuaggguucgauuccggagagggagccugagaaaua
gcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaa
aaaaaaagaugaggcagcgaaaagaaauagagccgacagugcuuuugcau
ugucguuuucaaugggggauauuuaaacccauccaaaaucgaguaacaau
uggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagc
guauauuaaugcuguugcuguuaaaggguucguaguugaauugagggccu
cuaaggcgcaaugguuuagucccauccacuucggauuggugacccaugcc
cuugugguccgugaacagacauucagaaacaaaaaacacgggagugguac
cuuuccugauuaucgcaugucaugcaugccagagggcgcccgugauuuuu
uacugugacuaaaaaagugugaccaaagcagucauucgacuugaauuaga
aagcaugggauaacaaaggagcagccucugggccaccguuucggcuuuug
uugguuuuaaaaguccauuggagauuauggggcagugugacaagcggcug
ggugcacucgucgccuuugcaacucacggcauccaggaaugaaggagggu
aguucgggggagaacguacuggugcgucagaggugaaauucuuagaccgc
accaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaauc
aagaaccaaaguguggggaucgaagaugauuagagaccauuguaguccac
acugcaaacgaugacacccaugaauuggggaguuuuuggucguaggcgug
gucgggcuugauuauuauuuuucaucccguuccucgucucgccaaugaau
auuaaauuuacgugcauauucuuuuuggucuucguuuuuuuacggcgagg
gccuuuaacgggaauauccucagcacguuaucugacuucuucacgcgaaa
gcuuugagguuacagucucaggggggaguacguucgcaagagugaaacuu
aaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauu
ugacucaacacggggaacuuuaccagauccggacagggugaggauugaca
gauugaguguucuuucucgauccccugaaugguggugcauggccgcuuuu
ggucgguggagugauuuguuugguugauuccgucaacggacgagauccaa
gcugcccaguaggauucagaauugcccccuuccgcggguuuuacccaagg
gggggcgguauucgcuuguauccuucucugcgggauuccuuguuuugcgc
aaggugagauuuugggcaacagcaggucugugaugcuccucaauguucug
ggcgacacgcgcacuacaaugucagugagaacaagaaaaacgacucuugu
cggaccuacuugaucaaaagagugggaaaaccccggaaucacguagaccc
acuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucg
uaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacac
accgcccgucguuguuuccgaugauggugcaauacaggugaucggacagu
cgagugcuucacuugaccgaaaguucaccgauauuucuucaauagaggaa
gcaaaagucguaacaagguagcuguaggugaaccugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[.[[.....<<<<<<...>>>>>>...<<...
..<<<<<<.....>>>>>>......>>..........<<<<<.<<<....
...<<<<<<<<<....>>>>>>>>>...>>>>>>>>.[[((((((((...
...<<<<<<<<<<<<......>>>.........................)
)))))))...]]....<<<<<<........>>>>>>...]].]]..]]]]
..]]].<<<....<<<....<<<<<.<<.......>>.>>>>>>>>....
..>>>..<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........
>>>.>>.<<<<....>>>>...]]]]]].........<<<....<<<...
.......>>>..>>>.......]]]....<<<.<<<<<<<<<....>>>>
>>>>>..>>>.....<<<<............>>>.....>.........<
<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..]]
]]]]}}}}.........{{{{{.....[[[[...[[[.......<<<<<.
<.<<<<.<<<..<<............................>>..>>>>
>>>>.>>>>>..........................<<<<<<..<....<
<<<.<.........<<<<.......>>>>..>>>>>.>>>>>>>.....<
<<<<<<<.......<<...<.......>..<<<....>>>.....>>...
...>>>>>..>>>...........[[..(((((..<<<...>>>.((..>
>>>>>>>>))..)))))..]].......<<<<<...<<<....<<<<<..
<<<..>>>.>>>>>..<<<>>>..>>>.>>.>>>............<<<<
<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>>
>>>>.>.>>.......<<....>>.>>>>>>..>>.>>>.>>....]]].
..]]]]...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>
>>>.........<<<.<<...<..<<<<<.......<<<.<<.<<<<<.<
<..<<<...<............>..>>>...>>.>>>>>>>>>>......
.....................<.<<...<<<<<<<.........>>>>>>
>.........>>.>................>>>>>..>......<<..}}
>>.....>>.....>>>.}}}.<<<......<<<<....>>>>....>>>
..}}}}..<<<<<.<<<<<<<..<<.<<<<<<.....<<<<<<.......
<<........>>.......<..<<.<<......<.<<<........<<.<
<<........>>>.>>......>>>.>.<.<<.<<<..<<.<<<<<<...
.<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<
.<<<<.....<<<<<.<<..<.....<<<<<<<..<<<<...>>>>..>>
>>>>>......>....>>.>>>>>.....>>>>...<<.<.<<.....>>
>.>>.......>>>>>....>>>.>>>.....>>>>>>>>......>.>.
>>.>...>.>>>>>....................................
....<<<<<<<........>>>>>>>........................
....<....<<<.<<..........>>.>>>.....>.....>>>>>>..
..<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<<
<<<<<<...>>>>>>>>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>
>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ase Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
Resolution3.33 Å
Binding residue
(original residue number in PDB)		L46 G47 N48 L49 R50 R66 G67 A68 V70 R71 K72 I75 R155
Binding residue
(residue number reindexed from 1)		L23 G24 N25 L26 R27 R43 G44 A45 V47 R48 K49 I52 R132
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ase, PDBe:7ase, PDBj:7ase
PDBsum7ase
PubMed33357443
UniProtA0A2V2WGW5

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