Structure of PDB 6gqb Chain w Binding Site BS01

Receptor Information
>6gqb Chain w (length=223) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKLNISYPVNGSQKTFEIDDEHRIRVFFDKRIGQEVDGEAVGDEFKGYVF
KISGGNDKQGFPMKQGVLLPTRIKLLLTKNVSCYRPRRDGERKRKSVRGA
IVGPDLAVLALVIVKKGEQELEGLTDTTVPKRLGPKRANNIRKFFGLSKE
DDVRDFVIRREVTKGEKTYTKAPKIQRLVTPQRLQRKRHQRALKVRNAQA
QREAAAEYAQLLAKRLSERKAEK
Ligand information
>6gqb Chain 2 (length=1776) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagucc
uuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggcguauugcucgaauauauuagcauggaauaauagaauagga
cguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucgggggcaucaguauucaauugucagaggugaaauucuuggauu
uauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgggugguguuuaugacccacuc
ggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucg
caaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggag
ccugcggcuuaauuugacucaacacggggaaacucaccagguccagacac
aauaaggauugacagauugagagcucuuucuugauuuugugggugguggu
gcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaa
cgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuau
ccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaa
uaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacac
ugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugu
gaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacg
aggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccug
cccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugag
gccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaa
uuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuc
cguaggugaaccugcggaaggaucau
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<<....<<
.<<.......>>.>>.....>>.........<<<<<............>>
>>>....<<<<<<......(((((((.<<<....>>>.............
.>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<.......<.<<...<<<.<<....<<<<<<.<<<
<<............>>>>>.>>>>>>.....<<<<<........<<<...
......>>>........>>>>>....<<<<<.<<.......<<...<...
....>..<<<.....>>>....>>......>>.>>..>>>.........<
<...<<<<<<<<.....))))))).>>>>>>>>..>>.....>>....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>.>.>>.......<<....>>...>>>>..>.>>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<.<<<...>>>>>>>>>
>>..>>>...<<....>>...>>.....>>>.>>>.<<<......<<<<.
...>>>>....>>>..]]]].}<<<<<.<<<<<<<....<.<<<<<.<<<
<.<<<<<<......<<........>>..........<<<<<......<<<
<<........<..<<<........>>>.>.......>>>>>.........
.....<<<<<<....<<<.<<<<......>>...<<<......>>>...>
>.>>>....<<<<<.<<.....<..<<<<<..<.<<<....>>>>.....
>>>>>..>....>>....<<<<<<.....>>>>>>.......>>>>>...
.>>>.>>>...................>>>>>...>>.>>>>.>>>.>..
.<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>...
....>>>>>>>......<....<<<<<<..........>>>>>>....>.
....>>>>>......<<<<<<<.......>>>>>>>.......>....>>
>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<
.<<..<...<<<<<<<.<<..................>>.>>>>>>>...
>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<
<<<<<<<..>>>>>>>>>>.......
Receptor-Ligand Complex Structure
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PDB6gqb Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
Resolution3.9 Å
Binding residue
(original residue number in PDB)
S6 Q13 K14 T15 R31 S53 N56 Q59 G60 Q65 G66 R72 L75 S82 C83 Y84 R85 R87 R88 D89 G90 R92 R94 K95 S96 V108 R132 L133 G134 P135 K136 R137 N139 N140 R154 R159 R160 V162 K164 Y169 T170 A172 P173 K174 I175 Q176 R177 Q182 R183 L184 Q185 R186 K187 R188 Q190 R191 K194 R196 Q199 Q201 R202 R219
Binding residue
(residue number reindexed from 1)
S6 Q13 K14 T15 R31 S53 N56 Q59 G60 Q65 G66 R72 L75 S82 C83 Y84 R85 R87 R88 D89 G90 R92 R94 K95 S96 V108 R132 L133 G134 P135 K136 R137 N139 N140 R154 R159 R160 V162 K164 Y169 T170 A172 P173 K174 I175 Q176 R177 Q182 R183 L184 Q185 R186 K187 R188 Q190 R191 K194 R196 Q199 Q201 R202 R219
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6gqb, PDBe:6gqb, PDBj:6gqb
PDBsum6gqb
PubMed29886014
UniProtP0CX37|RS6A_YEAST Small ribosomal subunit protein eS6A (Gene Name=RPS6A)

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