Structure of PDB 8qsj Chain v Binding Site BS01

Receptor Information
>8qsj Chain v (length=69) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APWSREAVLSLYRALLRQGRQLRYTDRDFYFASIRREFRKNQKLEDAEAR
ERQLEKGLVFLNGKLGRII
Ligand information
Ligand IDPM8
InChIInChI=1S/C21H41N2O7PS/c1-4-5-6-7-8-9-10-11-18(25)32-15-14-22-17(24)12-13-23-20(27)19(26)21(2,3)16-30-31(28)29/h19,26,31H,4-16H2,1-3H3,(H,22,24)(H,23,27)(H,28,29)/t19-/m0/s1
InChIKeyBPRKYNVKIAROET-IBGZPJMESA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO[PH](O)=O
ACDLabs 10.04O=C(SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)O)CCCCCCCCC
OpenEye OEToolkits 1.7.5CCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)C(C(C)(C)COP(=O)O)O
OpenEye OEToolkits 1.7.5CCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H](C(C)(C)CO[P@H](=O)O)O
CACTVS 3.385CCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[CH](O)C(C)(C)CO[PH](O)=O
FormulaC21 H41 N2 O7 P S
NameS-(2-{[N-(2-HYDROXY-4-{[HYDROXY(OXIDO)PHOSPHINO]OXY}-3,3-DIMETHYLBUTANOYL)-BETA-ALANYL]AMINO}ETHYL) DECANETHIOATE
ChEMBL
DrugBank
ZINCZINC000058660945
PDB chain8qsj Chain w Residue 200 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8qsj Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R6 E38 F39 N42 Q43 K44 R51 Q54 K57 G58 F61
Binding residue
(residue number reindexed from 1)		R5 E37 F38 N41 Q42 K43 R50 Q53 K56 G57 F60
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0140978 mitochondrial large ribosomal subunit binding
Biological Process
GO:0000266 mitochondrial fission
GO:0006417 regulation of translation
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042254 ribosome biogenesis
GO:0070131 positive regulation of mitochondrial translation
GO:1902775 mitochondrial large ribosomal subunit assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qsj, PDBe:8qsj, PDBj:8qsj
PDBsum8qsj
PubMed38042949
UniProtL0R8F8|MIDUO_HUMAN Mitochondrial ribosome and complex I assembly factor AltMIEF1 (Gene Name=MIEF1)

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