Structure of PDB 8eti Chain v Binding Site BS01

Receptor Information

>8eti Chain v (length=161) Species: 4896 (Schizosaccharomyces pombe)

ANPRQRNKQRSGKPRLTRRNANKKAKAKIYGNFVIQQNWDKHATLRQNYA
RLGLLATPNYVTGGVEKLYPDPTLDDVLDKEISIAPAKTEVVRQLEEEAV
KKAARQSNKMLPLSAFEHAYIQRLINKYGTEDFESMAKDVKLNSKLFNGS
KLKNLYIRMKA

Ligand information

>8eti Chain 1 (length=1579)

uugaccucaaaucagguaggacuacgcgcugauaagcgcaggaaaagaaa
auaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaa
aucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcu
uugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagg
gugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucg
aagagucgaguugcagcucuaaauggguggucaucuaaagcuaaauauug
gcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacu
uugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauugg
aaaucagucuuaccugggugagaucaguagucucucgagacuaugcacuc
uaaccuggguaggucagcaucaguuuucgggggcggaaaaagaauaaggg
aagguggcuguuuauagcccuuguuguaauacguccacuggggacugagg
acugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgu
cuaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaa
aacccauccgcgaaggugggaacgcccuuguggcgugcaccaucgaaaga
gcauagcuguugggacccgaaagauggugaaccaucuaguagcugguucc
ugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguaugua
aaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcg
ggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaag
aaaagguguuaguucaucuagacagcaggacgguggccauggaagucgga
auccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccuga
aaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuagc
uuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccu
ugggcgugagccugggucgaacagccucuagugcagaucuugguggaagu
agcagcgaaaccacagccuggggggccaggcaaaaucagcggcagucaag
cgcgacguugcuuuccuaucauaccgaagcagaauucgguaagcguggga
acugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaacc
guugauucagaucauugguauuugcggcgccgcggagcuaucaucugccg
gauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgaa
uguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcga
ugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaucg
aauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugc
ugagauuaagccuuuguucccaagauuug

........................<<<<<<....>>>>>.>.........
<<....>>..<<<<<......<<>>.....>>>>>..<<<..<.......
.<<.<<<<<<<.......>>>>>>>.>>........>....<<<<<.<<<
<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<
<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>.
.......<<<<<<>>>>>>.....<<<<<..>>>>>..>>>.........
.........................<<....>>...............<<
<<....>>>>..................................<<<<<<
<<<<<<.....<<<<<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>
>.>>>>>>>>..<<<<<<<<<<<<<<<<<<<<<<<........<<<<<<<
.................>>>>>>>.......>>>>>.>>>>>>>>>>...
.....<<<.....>>>....>>>>>>>>....>>>>>>>>>>>>..<<<<
.....>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<......
.>>>>...>>>...<<<<<..<<<<<.....>>>>>...>>>>>......
>>>>>>.>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<
<<<<......<<..>>..<<<<<<<<<<...<<<.<<<<<<<....>>>>
>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...
...<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>.
...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..
........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....
........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<
.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<....
.<<.>>....>>....<<<<<....>>>>>....<<<<<.<<<<<<...<
..>...>>>>>>.<<<...<.<<<<<<<......>>>>>>>...>.>>>.
.>>>>>......<<<<<<<..<<<<.<.<<<<<.................
>>>>>.><<<<<....<.<....<<<<..>>>>...>.>...>>>>>.<<
<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>.
...<<.......<<<<<<...>>.>>>>....>>........<<<<<...
.<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<
<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>
...>>>....>>>>.>>>>>...>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eti Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): A2 N3 R5 Q6 R7 K9 R16 L17 T18 R19 R20 K25 K29 I30 Y31 G32 Q37 H43 T45 R47 T63 G65 K155 F162 E163 K191 F193 N194 G195 S196 K199
• Binding residue (residue number reindexed from 1): A1 N2 R4 Q5 R6 K8 R15 L16 T17 R18 R19 K24 K28 I29 Y30 G31 Q36 H42 T44 R46 T62 G64 K109 F116 E117 K145 F147 N148 G149 S150 K153

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0030687 preribosome, large subunit precursor
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8eti, PDBe:8eti, PDBj:8eti
• PDBsum: 8eti
• PubMed: 36423630
• UniProt: Q9Y7Z1|NOP16_SCHPO Nucleolar protein 16 (Gene Name=nop16)