Structure of PDB 7nfx Chain v Binding Site BS01

Receptor Information
>7nfx Chain v (length=186) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RAVLLVGLCDSGKTLLFVRLLTGLYRDTQTSITDSCAVYRVNNNRGNSLT
LIDLPGHESLRLQFLERFKSSARAIVFVVDSAAFQREVKDVAEFLYQVLI
DSMGLKNTPSFLIACNKQDIAMAKSAKLIQQQLEKELNTLRVTGKEFEFS
QLPLKVEFLECSAKGGRGDVGSADIQDLEKWLAKIA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7nfx Chain v Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7nfx Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		T78 S95
Binding residue
(residue number reindexed from 1)		T14 S31
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0045047 protein targeting to ER
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005785 signal recognition particle receptor complex
GO:0005789 endoplasmic reticulum membrane
GO:0005881 cytoplasmic microtubule
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nfx, PDBe:7nfx, PDBj:7nfx
PDBsum7nfx
PubMed34020957
UniProtQ9Y5M8|SRPRB_HUMAN Signal recognition particle receptor subunit beta (Gene Name=SRPRB)

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