Structure of PDB 6g18 Chain v Binding Site BS01

Receptor Information

>6g18 Chain v (length=325) Species: 9606 (Homo sapiens)

LRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVK
HKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESD
IYIVANEEGQQFALKLHRLGRHNVSWLYLSRLSAMKEFAYMKALYERKFP
VPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGL
IHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFM
KRFSYESELFPTFKDIRREDTLDVESTIPPELVKQKVKRQLTKQQKSAVR
RRLQKGANIFTKQRRENMQNIKSSL

Ligand information

>6g18 Chain 2 (length=1658)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagagug
uucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggacc
gcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggac
ggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggc
gcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaauca
agaacgaaagucggagguucgaagacgaucagauaccgucguaguuccga
ccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgc
cgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguauggu
ugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggagugg
agccugcggcuuaauuugacucaacacgggaaaccucacccggcccggac
acggacaggauugacagauugauagcucuuucucgauuccguggguggug
gugcauggccguucuaguugguggagcgauuugucugguuaauuccgaua
acgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaac
uucuuagagggacaaguggcguucagccacccgagauugagcaauaacag
gucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacug
gcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauu
cgugauggggaucggggauugcaauuauuccccaugaacgaggaauuccc
aguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguac
accgcgucgcuacuaccgauuggaugguuuagugaggcccucggaucggc
cccgccggggugcccuggcggagcgcugagaagacggucgaacuugacua
ucuagaggaaguaaaagucggguuuccguaggugaaccugcggaaggauc
auuaacgg

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<.......
....>..>>.........<<<<<((....<.<<<<.....<<..))>>..
.....>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.
......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<
.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<
<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>
>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>..
.>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>
>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>
>>.>..>>>...<<.)).>>...>>.....>>>.>.>.<<<......<<<
<....>>>>....>>>..)))).]..<<<.<<<<<<<..<<..<<<<<..
<<<.<<<<<<............................<<<<<.<....<
<<<<<.......<<.<<<........>>>.>>.....>>>>>>......<
<<<<<<<<<<<<<...<<<.<<<<<....>>>...<<<......>>>...
>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>
>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>
>>>.>>>.>>>>.......>.>>>>>...>>.>>>>.>>>.....<<.<<
<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>
>......<.....<<<<<..........>>>>>.....>.....>>>>>.
....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..
<<<.<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<
<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>
>>>...>>.>>>>...>.>>>>><<<<<<<<<....>>>>>>>>>.....
........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6g18 Visualizing late states of human 40S ribosomal subunit maturation.
• Resolution: 3.6 Å
• Binding residue (original residue number in PDB): R14 H30 K51 R54 K68 V103 K105 D228 N230 F232 K275 K502 K504 K523
• Binding residue (residue number reindexed from 1): R6 H22 K43 R46 K60 V95 K97 D204 N206 F208 K251 K284 K286 K305

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0044024 histone H2AS1 kinase activity
• GO:0046872 metal ion binding
• GO:0106310 protein serine kinase activity

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006468 protein phosphorylation
• GO:0016310 phosphorylation
• GO:0030071 regulation of mitotic metaphase/anaphase transition
• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis
• GO:0042274 ribosomal small subunit biogenesis
• GO:0046777 protein autophosphorylation
• GO:2000208 positive regulation of ribosomal small subunit export from nucleus
• GO:2000234 positive regulation of rRNA processing

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0030688 preribosome, small subunit precursor

External links

• PDB: RCSB:6g18, PDBe:6g18, PDBj:6g18
• PDBsum: 6g18
• PubMed: 29875412
• UniProt: Q9BVS4|RIOK2_HUMAN Serine/threonine-protein kinase RIO2 (Gene Name=RIOK2)