Structure of PDB 5gjr Chain v Binding Site BS01
Receptor Information
>5gjr Chain v (length=380) Species:
9606
(Homo sapiens) [
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QVEDDIQQLLKKINELTGIKESDTGLLAADKQTLQSEQPLQVARCTKIIN
ADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPL
PPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVN
LGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEG
ARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELI
NQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTH
IFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKI
ATEKDFLEAVNKVIKSYAKFSATPRYMTYN
Ligand information
Ligand ID
ADP
InChI
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey
XTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341
Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04
O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
Formula
C10 H15 N5 O10 P2
Name
ADENOSINE-5'-DIPHOSPHATE
ChEMBL
CHEMBL14830
DrugBank
DB16833
ZINC
ZINC000012360703
PDB chain
5gjr Chain v Residue 501 [
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Receptor-Ligand Complex Structure
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PDB
5gjr
An atomic structure of the human 26S proteasome.
Resolution
3.5 Å
Binding residue
(original residue number in PDB)
D176 G178 P218 G219 T220 G221 K222 T223 L224 G382 A383
Binding residue
(residue number reindexed from 1)
D123 G125 P165 G166 T167 G168 K169 T170 L171 G329 A330
Annotation score
5
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0016887
ATP hydrolysis activity
GO:0036402
proteasome-activating activity
Biological Process
GO:0001649
osteoblast differentiation
GO:0006511
ubiquitin-dependent protein catabolic process
GO:0043161
proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800
positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502
proteasome complex
GO:0000932
P-body
GO:0005576
extracellular region
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0008540
proteasome regulatory particle, base subcomplex
GO:0016020
membrane
GO:0022624
proteasome accessory complex
GO:0034774
secretory granule lumen
GO:0036464
cytoplasmic ribonucleoprotein granule
GO:1904813
ficolin-1-rich granule lumen
View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:5gjr
,
PDBe:5gjr
,
PDBj:5gjr
PDBsum
5gjr
PubMed
27428775
UniProt
P35998
|PRS7_HUMAN 26S proteasome regulatory subunit 7 (Gene Name=PSMC2)
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