Structure of PDB 8eui Chain u Binding Site BS01

Receptor Information

>8eui Chain u (length=59) Species: 4896 (Schizosaccharomyces pombe)

RVHTCYFCSGPVYPGHGIMFVRNDSKVFRFCRSKCHKNFKMKRNPRKVAW
TKAYRKAHG

Ligand information

>8eui Chain 1 (length=2855)

uugaccucaaaucagguaggacuacgcgcugaacuuaagcauaucaauaa
gcgcaggaaaagaaaauaaccaugauucccucaguaacggcgagugaagc
gggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgagu
uguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuu
ggaacaggacgucagagagggugagaaccccgucuuuggucgauuggaua
ugccauauaaagcgcuuucgaagagucgaguuguuugggaaugcagcucu
aaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgaua
gcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguu
aaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuaua
ggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcugu
uuauagcccuuguuguaauacguccacuggggacugaggacugcggcuug
ccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggac
caaggagucuagcaucuaugcgaguguuugggugaaaaacccauccgcga
aaugaaagugaaugcaggugggaacgcccuggcgugcaccaucgaccgac
ccggaaguuugucaauggaaggguuugaguaagagcauagcuguugggac
ccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucu
gguggaggcucguagagauucugacgugcaaaucgaucuucaaauuuggg
uauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaa
guuucccucaggauagcagaaacucagaucaguuuuaugagguaaagcga
augauuagagguaccuauucucaaacuuuaaauauguaagacgcccuugu
cgcuuaauuggacgugggccaucgaaugagaguuucuagugggccauuuu
ugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggug
ccggaauguacgcucaucagacaccagaaaagguguuaguucgaacuagc
ccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggg
uuaagaagcucagacgaguaggcaggcguggagguuugugacgaagccuu
gggcgugagccugggucgaacagccucuagugcagaucuugguggaagua
gcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccau
gugaacagcaguuggacauggguuagucgauccuaagagauagggaagcu
ccguaugaaaggcacgauuuuucgugccuaucgaaagggaauccgguuaa
uauuccggaaccagaagguggaaucaacacggcaacguaaaugaaguugg
agacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaacc
acacccugaaaucgguuuauccggagcuaggguaugguguuuggaagagu
ucagcggcugaauccggugcgcucucgacggcccuugaaaauccaacgga
aguguuuucacaucuggucguacucauaaccgcagcaggucuccaaggug
aacagccucuaguugauagaacaauguagauaagggaagucggcaaaaug
gauccguaacuucgggauaaggauuggcucuaaggguaucaacuuagaac
ugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcga
uggccagaaagugguguugacgcaaugugauuucugcccagugcucgaau
gucaaagugaagaaauucaaccaagcgcggguaaacggcaagguagccaa
augccucgucaucuaacuagugacgcgcaugaauggauuaacgagauucc
cacugucccuaucuacuaucuagcgaaaccacagccuggggaacgggcca
ggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuuga
cauugugaauuacuuaaucaaugaagcggaauuucuagcguuaaaguuuc
gcgaacugauccgcguugaugacauugucagguggggaguuuggcugggg
cggcacaucuguuaaaagauaacgcagguguccuaagggggacucaucga
gaaucucgaguagaauaaaaggguaaaaguccccuugauuuugauuuuca
gugugaauacaaaccaugaaaguguggccuaucgauccuuuguucccucg
aaauuugaggacagaggugccagaaaaguuaccacagggauaacuggcuu
cagccaagacguugcauucuucgaugucggcucuuccuaucauaccgaau
ucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguu
uagaccgucgugagacagguuaguuuuacccuacugaugaagugucgucg
caaugguaauucaacuuaguacgggaaccguugauucagaucauugguau
uugcggcugccugacaaggcaaugccgcggagcuaucaucugccggauaa
cggcugagccagaauccgugccagaaagcgacgauuuauguauaaaaaua
gaguccuguaucguagaagaugggcgaugguugaacggaaguguuuugac
uuguccaugaaauuccagaauccauugcauacgacuuuaauguggaacgg
gguauuguaagcaguagagaucugcugagauuaagccuuuguucccaaga
uuugu

........................<<<<<<.....<......>......>
>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<...........<<.<<<<<<<.......>>>>>>>.>>..
...........<<<<<.<<<<<..<<<<<..<<<<.<<<<.....<<<<.
.....>>>>.((......<<<.....))>>>......>>>>.>>>>..>>
>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.
....<<<<<..((((((>>>>>..>>>....>..................
...........<<....>>...............<<<<....>>>>....
..............................<<<<<<<<<<<.<...<..>
.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<.....<....>
......>>>>>>>>....>.>>>>>.>>>>>>>>>>........<<<..>
>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<
<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>..
.<<....>>.......<<<<<..<<<<<..>>>>>...>>>>>.<<<<<<
<<....<<<....>>>....>>>.>>>.>>....>>>>>>.>>>>>>..<
<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>
>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>
>>>...<<.......>>......>>>>>>......>.>>..<<<<<<...
.<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<...
.<<<....<<<..>>>....>>>..>.>>.....>>>>>...<<<<.<<<
<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(
((.....<<<<<<......<..........<<<.<<<<<<<..>>>>>>>
>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<
<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.
<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....
<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<
<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>
>>........<<<<<<......>>>>>>..>>....>>...<<<<<....
....>>>>>))<<<<..<<<<<<<....<<<....>>>.....((<<<<<
<...<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>><...<<<<<.
..<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<
<<<<<.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...
...>>>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.
....>>>>..>>>>..<<<<.....<<<<<<<.<<...............
<<<<<....<....>.....>>>>><<.<<<<<<<<..>>..>>>>>>.>
>............<<<<<<<<<..<<<.........>>>..<<<<<<<..
..<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<<..<
<<....<<<<<....>>>>.>...>>>>>>>>..>>>>.......<....
.......<<<<<.......>>>>>.....>.....>>....>>.>>>>>>
>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>
>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<
<<..<<<...>>>...<<<<<.....<<<<..........))..<<<<<.
..>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<....
.>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<
<<.>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<...
....>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.
))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<...
<<<<......>>>>..>.>.......<<<<<.<<<<<<..<.<<<<<<..
>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>..
..<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<<
<..<<<<...<<<<<..............>>>>>..<<<<<...<<<<..
..<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...
.<<<<.>>>>....>>>>.>>>>....>>>>>>>>......<<.......
<<.>>....>>........<<<<<....<<<<.<<<......>>>..>>>
>..>>>>>.........<<<<<.<.............>.....<<<<<<<
<<.<<<....<<<<.<....>>>>>...>>>....>>>>.>>>>>...>>
>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eui Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): G16 G18 I19 S34 K35 K38 M42 R44 K48 A50 W51 R56 H59
• Binding residue (residue number reindexed from 1): G15 G17 I18 S33 K34 K37 M41 R43 K47 A49 W50 R55 H58

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:8eui, PDBe:8eui, PDBj:8eui
• PDBsum: 8eui
• PubMed: 36423630
• UniProt: Q10353|RLP24_SCHPO Ribosome biogenesis protein rlp24 (Gene Name=rlp24)