Structure of PDB 8eug Chain u Binding Site BS01

Receptor Information

>8eug Chain u (length=59) Species: 4896 (Schizosaccharomyces pombe)

RVHTCYFCSGPVYPGHGIMFVRNDSKVFRFCRSKCHKNFKMKRNPRKVAW
TKAYRKAHG

Ligand information

>8eug Chain 1 (length=2869)

uugaccucaaaucagguaggacuacgcgcugaacuuaagcauaucaauaa
gcgcaggaaaagaaaauaaccaugauucccucaguaacggcgagugaagc
gggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgagu
uguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuu
ggaacaggacgucagagagggugagaaccccgucuuuggucgauuggaua
ugccauauaaagcgcuuucgaagagucgaguuguuugggaaugcagcucu
aaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgaua
gcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguu
aaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuacg
uaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcu
guuuauagcccuuguuguaauacguccacuggggacugaggacugcggcu
ugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacgg
accaaggagucuagcaucuaugcgaguguuugggugaaaaacccauccgc
gaaaugaaagugaaugcaggugggaacgcccuggcgugcaccaucgaccg
acccggaaguuugucaauggaaggguuugaguaagagcauagcuguuggg
acccgaaagauggugaacuaugccugaauagggugaagccagaggaaacu
cugguggaggcucguagagauucugacgugcaaaucgaucuucaaauuug
gguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccg
aaguuucccucaggauagcagaaacucagaucaguuuuaugagguaaagc
gaaugauuagagguaccuauucucaaacuuuaaauauguaagacgcccuu
gucgcuuaauuggacgugggccaucgaaugagaguuucuagugggccauu
uuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaagg
ugccggaauguacgcucaucagacaccagaaaagguguuaguucgaacua
gcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucug
gguuaagaagcucagacgaguaggcaggcguggagguuugugacgaagcc
uugggcgugagccugggucgaacagccucuagugcagaucuugguggaag
uagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucc
augugaacagcaguuggacauggguuagucgauccuaagagauagggaag
cuccguaugaaaggcacgauuuuucgugccuaucgaaagggaauccgguu
aauauuccggaaccagaagguggaaucaacacggcaacguaaaugaaguu
ggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaa
ccacacccugaaaucgguuuauccggagcuaggguaugguguuuggaaga
guucagcggcugaauccggugcgcucucgacggcccuugaaaauccaacg
gaaguuguuuucacaucuggucguacucauaaccgcagcaggucuccaag
gugaacagccucuaguugauagaacaauguagauaagggaagucggcaaa
auggauccguaacuucgggauaaggauuggcucuaaggguaucaacuuag
aacugguacggacaaggggaaucugacugucuaauuaaaacauagcauug
cgauggccagaaagugguguugacgcaaugugauuucugcccagugcucg
aaugucaaagugaagaaauucaaccaagcgcggguaaacggcaagguagc
caaaugccucgucaucuaacuagugacgcgcaugaauggauuaacgagau
ucccacugucccuaucuacuaucuagcgaaaccacagccuggggaacggg
ccaggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguu
ugacauugugaauuuacuuaaucaaugaagcggaauuucuagcguuaaag
uuucgcgaacugauccgcguugaugacauugucagguggggaguuuggcu
ggggcggcacaucuguuaaaagauaacgcagguguccuaagggggacuca
ucgagaaucucgaguagaauaaaaggguaaaaguccccuugauuuugauu
uucagugugaauacaaaccaugaaaguguggccuaucgauccuuuguucc
cucgaaauuugaggacagaggugccagaaaaguuaccacagggauaacug
gcuucagccaagacguugcauucuucgaugucggcucuuccuaucauacc
gaauucgguaagcguuggauuguucacccacuaauagggaacgugagcug
gguuuagaccgucgugagacagguuaguuuuacccuacugaugaaguguc
gucgcaaugguaauucaacuuaguacgggaaccguugauucagaucauug
guauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccgg
auaacggcugagccagaauccgugccagaaagcgacgauuuauguauaaa
aauagagguaacucuccuguaucguagaagaugggcgaugguugaacgga
aguguuuugacuuguccaugaaauuccagaauccauugcauacgacuuua
auguggaacgggguauuguaagcaguagagucgaucugcugagauuaagc
cuuuguucccaagauuugu

........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<...........<<.<<<<<<<.......>>>>>>>.>>..
...........<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<.
.....>>>>.((......<<<.....))>>>......>>>>>>>>>..>>
>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.
....<<<<<..((((((>>>>>..>>>.......................
...........<<....>>...............<<<<....>>>>....
..............................<<<<<<<<<<<.<...<<..
>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<..
.>......>>>>>>>>....>.>>>>>.>>>>>>>>>>........<<<.
.>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>>
<<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>
...<<....>>.......<<<<<..<<<<<..>>>>>...>>>>>.<<<<
<<<<....<<<....>>>....>>>.>>>.>>....>>>>>>.>>>>>>.
.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>
>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>
>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<.
...<<<....<<<..>>>....>>>..>.>>.....>>>>>...<<<<.<
<<<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<
<(((.....<<<<<<.....<<..........<<<.<<<<<<<..>>>>>
>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<
<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<...
..<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<...
.>>>........<<<<<<......>>>>>>..>>....>>...<<<<<..
......>>>>>))<<<<..<<<<<<<....<<<....>>>.....((<<<
<<<...<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>>....<<<<
<...<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....
<<<<<<<.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.
......>>>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<
<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<............
...<<<<<...............>>>>><<.<<<<<<<<..>>..>>>>>
>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<
<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<<
..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>.......<.
..........<<<<<.......>>>>>.....>.....>>....>>.>>>
>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........
>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<
<<<<<..<<<<..>>>>...<<<<<.....<<<<..........))..<<
<<<...>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<
.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...
<<<<<<.>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<
<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<
<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<
<...<<<<......>>>>..>.>.......<<<<<.<<<<<<..<.<<<<
<<..>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.
>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<
<<<<<..<<<<...<<<<<..............>>>>>..<<<<<...<<
<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<
<....<<<<.>>>>....>>>>.>>>>....>>>>>>>>......<<...
....<<<<....>>>>....>>........<<<<<....<<<<.<<<...
...>>>..>>>>..>>>>>.........<<<<<.<.............>.
....<<<<<<<<<.<<<....<<<<....<.>...>>>>...>>>....>
>>>.>>>>>...>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eug Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): G16 I19 R33 S34 K35 K38 R44 K48 A50 W51 R56
• Binding residue (residue number reindexed from 1): G15 I18 R32 S33 K34 K37 R43 K47 A49 W50 R55

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:8eug, PDBe:8eug, PDBj:8eug
• PDBsum: 8eug
• PubMed: 36423630
• UniProt: Q10353|RLP24_SCHPO Ribosome biogenesis protein rlp24 (Gene Name=rlp24)