Structure of PDB 8eth Chain u Binding Site BS01

Receptor Information

>8eth Chain u (length=58) Species: 4896 (Schizosaccharomyces pombe)

MRVHTCYFCSGPVYPGHGIMFVRNDSKVFRFCRSKCHKNFKMKRNPRKVA
WTKAYRKA

Ligand information

>8eth Chain 1 (length=1303)

uugaccucaaaucagguaggacuacgcgcuaagcgcaggaaaagaaaaua
accaugauucccucaguaacgugaagcgggaaaagcucaaauuugaaauc
uggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuug
aguguagacgaucggucuaaguuccuuggaacaggacgucagagagggug
agaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaag
agucgaguugugcagcucuaaauggguggucaucuaaagcuaaauauugg
cgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuu
ugaaaagagaguuaaauaguacgugaaauugcugaaagcauuggaaauca
gucuuaccugggugagaucaguagucucucgagacuaugcacucugaacc
ugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagg
uggcuguuuauagcccuuguuguaauacguccacuggggacugaggacug
cggcuucgugccaaggaugcugacauaaugguuuucaauggcccguccac
ggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccau
ccgcgaggugggaacgcccuggcgugcaccaucagagcauagcuguuggg
acccgaaagauggugaaccaucuaguagcugguuccugccgaagagcaga
aacucagaucaguuuuaaaugagaguuucuagugggccauuacuggcgau
gcgggccgaacgugagguuaaggugccggaauguacgcuagaaagguguu
aguuaacuagcccugggcgcuuaagcguacuacccauaccucaccgucug
gguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugac
gaagccuugggcgugagccugggucgaacagccucuagugcagaucuugg
uggaaguagcagcgaaaccacagccugggggccaggucgucgcaauggua
auucaacuuaguacggaaccguugauucagaucauugguagagcuaucau
cugccggauaacggcugagccagaauccgugccagagcgacgauauguau
aaaaauagaggucucuccuguaucguagaagaugggcgaugguugaugaa
acggaaguguuuuauugacuuguccaugaaauuccagaauccauugcaua
cgacuuuaauguggaacgggguauuguagauuaagccuuuguucccaaga
uuu

........................<<<<<<.>>>>>.>.........<<.
...>>..<<<<<......<<>>.....>>>>>..<<<..<<.......<<
.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<.
.<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<..
...))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>....
....<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>..........
........................<<....>>...............<<<
<....>>>>.............................<<<<<<<<<<<<
.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>..>>>
>..>>>..<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<....
..<...>......>>>>>>>>......>>>>>.>>>>>>>>>>.......
.<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<..>>
>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.......>>>>..
.>>>...<<<<..<<<<<..>>>>>...>>>>....>>>>>>.>>>>>>>
.<<.<...<<<<<<..>>>>>>......>.>>..<<<<<<.....<<<<<
<<<.....<<<.<<...>>>>>..>>>>>>.>>..<<<<....>>>>...
.<<<.>>>...<<<<<<<...<<<(((.....<<<<<<.<<..<<<.<<<
<<<..>>>>>>>>>.))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<............>>>>>>>>>....>>>>>>..<<<<<<<<.<<...
...<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>
><<.....<<.>>....>>....<<<<<...>>>>><<<<<<<..<<<<.
<.<<<<<......<>.....>>>>>.><<<<<...<<<<...>>>>..>>
>>>.<<<<....<<<<.>>>>....>>>>.>>>>..>>>>>>>.....<<
.......<<<<..>>>>....>>........<<<<<....<<<<<<<<<<
<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.......
......>.....<<<<<<<<<.<<<...>>>....>>>>.>>>>>...>>
>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eth Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): G16 H17 G18 K35 V49
• Binding residue (residue number reindexed from 1): G16 H17 G18 K35 V49

Gene Ontology

Molecular Function

• GO:0003674 molecular_function

Biological Process

• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:8eth, PDBe:8eth, PDBj:8eth
• PDBsum: 8eth
• PubMed: 36423630
• UniProt: Q10353|RLP24_SCHPO Ribosome biogenesis protein rlp24 (Gene Name=rlp24)