Structure of PDB 7wtt Chain u Binding Site BS01

Receptor Information
>7wtt Chain u (length=642) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRPGPLKQQNKAHKGLSRVDQRHRASQLRKQKKEAVLAEKRQLGGKDGPP
HQVLVVPLHSRISLPEAMQLLQGTVHLNELGNTQNFMLLCPRLKHRWFFT
SARPGDLHVVLDMAKVADTILFLLDPLEGWDSTGDYCLSCLFAQGLPTYT
LAVQGISGLPLKKQIDTRKKLSKAVEKRFPHDKLLLLDTQQEAGMLLRQL
ANQKQQHLAFRDRRAYLFAHAVDFVPSEENNLVGTLKISGYVRGQTLNVN
RLLHIVGYGDFQMKQIDAPGDPFPLNPKVLMKADPGRQESLQAEVIPDPK
VPKGTSSYQAEWIDEEAEAKMLEKYKQERLEEMFPDEVDTPRDVAARIRF
QKYRGLKSFRTSPWDPKENLPQDYARIFQFQNFTNTRKSIFKEVEEKEVE
GAEVGWYVTLHVSEVPVSVVECFRQGTPLIAFSLLPHEQKMSVLNMVVRR
DPGNTEPVKAKEELIFHCGFRRFRASPLFSQHTAADKHKLQRFLTADMAL
VATVYAPITFPPASVLLFKQKSNGMHSLIATGHLMSVDPDRMVIKRVVLS
GHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPLGTHGH
MKCSFDGKLKSQDTVLMNLYKRVFPKWTYDPYVPEPVPWLKS
Ligand information
>7wtt Chain 2 (length=1575) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccaauuccagcuc
caauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucu
cucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
cgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuu
uguugguuuucggaacugaggccaugauuaagagggacggccgggggcau
ucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggacc
agagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaaguc
ggagguucgaagacgauaccgucguaguuccgaccauaaacgaugccgac
cggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaa
accaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gcacccggcccggacacggacaggauugacagauugauagcucuuucucg
auuccgugggugguggugcauggccguuguuggcugguuaauuccgauga
acgagacucuggcaugcuauucuuagagggacaaguggcguucagccacc
cgagauugagcuaacaggucugugaugcccuguccggggcugcacgcgcg
cuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccg
uugaaccccauucgugauggggaucggggauugcaauuauuccccaugaa
cgaggaauucccaguaagugcgggucauaagcuugcguugauuaaguccc
ugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagug
aggcccucggaucggccccgccggggugcccuggcggagcgcugagaaga
cggucgaacuugacuaucuagaggaaguaaaagucgagguuuccguaggu
gaaccugcggaaggaucauuaacgg
...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.......
....>..>>.........<<<<<........<<<<........>>>>.>>
>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...
<<.<<<..>>>>>...<<<<<<.........<<...<.......>.<<<<
.>>>>...>>........>>>..>>>........<.<<.<<<<<<<....
...........>>>>>>>.>>.>....>>....<<<<<<..<...<<<<.
.<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>....
...<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<
<<<<...<...<<<<....>>>>...>>>>>>>>..........<<<.<<
.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..)
)>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>.
.)))).]]....<<<<<<<<..<<..<<<<<.<<<<.<<<<<<.......
...<<<<<....<.<<<<<<.......<<.<<<........>>>.>>...
..>>>>>>..>...<<<.<<.<<<<<<.<<<...<<<......>>>...>
>>....<<<...<...<<<....>>>..>.....<<<<<.....>>>>>.
.......>>>...>>.>>>>..>>..>>>....>>>>>...>>.>>>>.>
>>.>...<<.<<<........<.<<<.<<<<....>>>>.>>>....>..
.......>>>.>>......<.....<<<<<..........>>>>>.....
>.....>>>>>.....<<<<<<<<<.....>>>>>>>>>......>>...
>>>>>>>>......<<<...<<....<<<<.<<....<<<<<<<<.<<<.
.<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>
.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>.>>><<<<<<<<<.
...>>>>>>>>>.............
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wtt The nucleoplasmic phase of pre-40S formation prior to nuclear export.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H4 R5 P6 L9 Q11 N13 K14 A15 H16 K17 S49 R50 Q53 R54 H55 R56 Q59 L60 R61 Q63 K64 K65 V68 K72 K130 K219 R234 N238 K240 Y400 F484 S508 R738 L745 K752
Binding residue
(residue number reindexed from 1)		H1 R2 P3 L6 Q8 N10 K11 A12 H13 K14 S17 R18 Q21 R22 H23 R24 Q27 L28 R29 Q31 K32 K33 V36 K40 K94 K183 R198 N202 K204 Y308 F334 S358 R588 L595 K602
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0030688 preribosome, small subunit precursor

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7wtt, PDBe:7wtt, PDBj:7wtt
PDBsum7wtt
PubMed36321656
UniProtQ2NL82|TSR1_HUMAN Pre-rRNA-processing protein TSR1 homolog (Gene Name=TSR1)

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