Structure of PDB 7pfa Chain u Binding Site BS01

Receptor Information
>7pfa Chain u (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGPPVSELITKAVAASKERSGVSLAALKKALAAAGYDVEKNNSRIKLGLK
SLVSKGTLVQTKGTGASGSFKLNKK
Ligand information
>7pfa Chain I (length=561) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccgccatactggagaatcccggtgccgaggccgctcaattggtcgtag
acagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgtttta
accgccaaggggattactccctagtctccaggcacgtgtcagatatatac
atcctgtcatgtaagtattaaggtaacccagtactgtctcgcgcactggc
cgccatactggagaatcccggtgccgaggccgctcaattggtcgtagaca
gctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaacc
gccaaggggattactccctagtctccaggcacgtgtcagatatatacatc
ctgtcatgtaagtattaaggtaacccagtactgtctcgcgcactggccgc
catactggagaatcccggtgccgaggccgctcaattggtcgtagacagct
ctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgcc
aaggggattactccctagtctccaggcacgtgtcagatatatacatcctg
tcatgtaagta
Receptor-Ligand Complex Structure
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PDB7pfa Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution9.7 Å
Binding residue
(original residue number in PDB)		P38 R53 K80
Binding residue
(residue number reindexed from 1)		P4 R19 K46
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031490 chromatin DNA binding
GO:0031492 nucleosomal DNA binding
GO:0042826 histone deacetylase binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030261 chromosome condensation
GO:0045910 negative regulation of DNA recombination
Cellular Component
GO:0000786 nucleosome
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pfa, PDBe:7pfa, PDBj:7pfa
PDBsum7pfa
PubMed35581345
UniProtP10412|H14_HUMAN Histone H1.4 (Gene Name=H1-4)

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