Structure of PDB 7oie Chain u Binding Site BS01

Receptor Information
>7oie Chain u (length=111) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFDIDMMVSLLRQENARDICVIQVPPEMRYTDYFVIVSGTSTRHLHAMAF
YVVKMYKHLKCKRDPHVKIEGKDTDDWLCVDFGSMVIHLMLPETREIYEL
EKLWTLRSYDD
Ligand information
>7oie Chain A (length=1472) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacaaauaaaguauaggcgauagaaauugauggcgcaauaga
uauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagc
aaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuu
ugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaag
aacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuau
agguagaggcgacaaaccuaccgagccuggugauagcugguuguccaaga
uagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuugu
aaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaa
aaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagc
agccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacau
auaacugaacuccucacacccaauuggaccaaucuaucacccuauagaag
aacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccu
gcgucagauacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaag
guuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuacca
aaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagug
acacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuu
guuccuuaaauagggaccuguaugaauggcuccacgaggguucagcuguc
ucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaa
cacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaaca
guaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaa
ccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauu
gauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgca
auccuauucuagaguccauaucaacaauaggguuuacgaccucgauguug
gaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaa
cgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgg
uuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggc
cuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagau
acccacacccaagaacaggguu
<<<.......<<<<....................................
<......>.............<<.....>>.........>>.>>......
.......<<....>>......................>>>..........
.<<<.......>>>...<............>.<<<<<<.........<<<
.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<
<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>
>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<..
..<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>.....>>
>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>...<<<....
..>>>....<<<.<<<...<..............<....<<<........
.>>>....>.......<<<......>>>......................
.....>...>>>>>>........>>>>>>...<<<<<......>>>>>..
.......>>>>>><......<<..<<<....>>><<<<..<<<<......
..<<<<<...>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<......>>.>>>>.....>>>>..<
<<<...<<<<<<<<.<<.........<......<<<<<<..<<<......
...>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<
<<....>>>..>>>>><<<<<....>>>>>........<...........
<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>
>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>....
...<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<....
......>>>>>>>>.>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.....
....<<<....>>>............>>>>..>>>>>>.......<<<..
<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.........<
<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>
>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>..
..>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<
...<<<....>>>.>>>>>......<<<................>>>...
......<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7oie A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		H136 F140 K144 K147 K158
Binding residue
(residue number reindexed from 1)		H46 F50 K54 K57 K68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0043023 ribosomal large subunit binding
GO:0140978 mitochondrial large ribosomal subunit binding
Biological Process
GO:0017148 negative regulation of translation
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:0070130 negative regulation of mitochondrial translation
GO:0090071 negative regulation of ribosome biogenesis
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7oie, PDBe:7oie, PDBj:7oie
PDBsum7oie
PubMed34315873
UniProtQ96EH3|MASU1_HUMAN Mitochondrial assembly of ribosomal large subunit protein 1 (Gene Name=MALSU1)

[Back to BioLiP]