Structure of PDB 7oh3 Chain u Binding Site BS01

Receptor Information

>7oh3 Chain u (length=150) Species: 559292 (Saccharomyces cerevisiae S288C)

MRIYQCHFCSSPCYPGHGIMFVRNDAKEFRFCRSKCHKAFKQRRNPRKLK
WTKAFRKAAGKELAVDSTLTFAQRRNVPVRYNRELVATTLKAMARIEEIR
QKRERAFYKNRMRGNKEKDFLRDKKLVESNPELLRIREVEIARKLAKEQE

Ligand information

>7oh3 Chain 1 (length=3013)

guugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaaua
agcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaag
cggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaa
uuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaaca
ggacgucauagagggugagaaucccguguggcgaggagugcgguucuuug
aaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucag
uuuugguggcaggauaaauccauaggaauguagcuugccugguaaguauu
auagccugugggaauacugccagcugggacugaggacugcgacguaaguc
aaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggacca
aggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaa
ugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgau
ccugaugucuucggauggauuugaguaagagcauagcuguugggacccga
aagauggugaacuaugccugaauagggugaagccagaggaaacucuggug
gaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguaua
ggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuu
cccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaac
uuuaaauauguaagaaguccuuguuugaacguggacaugaaugaagagcu
uuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccga
acguagaguuaaggugccggaauacacgcucaucagacacacaaaaggug
uuaguucaucuagacagccggacgguggccauggaagucggaauccgcua
aggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggau
ggcgcucaagcguguuaccuauacucuaccgucaggguugugaugcccug
acgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucg
ggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaa
ugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguu
ggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggc
cuaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauau
ggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccu
gggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuu
auccggagauggggucuuauggcuggaagaggccagcacugcuggcuccg
gugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaug
ccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuag
uugauagaauaauguagauaagggaagucggcaaaauagauccguaacuu
cgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguac
ggacaaggggaaucugacugucuaauuaaaacauagcauugcgaugguca
gaaagugauguugacgcaaugugauuucgcccagugcucugaaugucaaa
gugaagaaauucaaccaagcgcggguaaacggcgggaguaugacucucuu
aagguagccaaauggauuaacgagauucccacugucccuaucuacuaucu
agcgaaaccacagccaagggggcuuggcagaaucagcggggaagaagacc
cugugagcuugacucuaguuugacauugugaagagacauaguuucuuuac
uuauucaaugaagcggagcuggaauuauuuuccacguucuagcauucaag
gucccucggggcugauccgguugaagacauugucagguggggaguuuggg
ggcggcacaucuguuaaacgauaagcagauguccuaaggggggcucaugg
agaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuug
auuuucagugugaauacaaaccaugaaaguguggccuaucgaucuuuagu
cccucggaauuugaggcuagaggugccagaaaguuaccacagggauaacu
ggcuuguggcagucaagcguucagcgacauugcuuuugauucuucgaugu
cggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguuc
acccacuaauagggaguagcuggguuuagaccgucgugagacagguuagu
uuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgaga
ggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauu
gccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucaga
auccaugcuagaacgcggugauuucugcuccacacaauauagauggauac
gaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggu
gcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauu
uugcguggggauaaaucauuuguauacgacuuagauguacaacgggguau
uguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuug
uugucugauuugu

.........................<<<<<<.....<<....>>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......
>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>
>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>...
>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<
<..((((((>>>>>..>>>...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<.<<<<<......<<<<<<<.<<<
<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<...>>>>>>...
....>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>
.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<
<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<
<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<
<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<.
..<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.
....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>.
..<<.......>>......>>>>>>......>.>>..<<<<<<....<.<
<<....>>>.><<.<<<<......<<<.<<<<<<....<..<........
.>..>....>>>>...<<<<.<<<....>>>.>>>>...>>>>>....>>
>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>.
..<<<<<<<..<<<<(((.....<<<<<<.....<<.........<<<.<
<<<<<<<<<.......<<<<<.<<....<<.........>>....>>...
......<<......>>...>>>>>...>>>>>>>>>>>>>..........
))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>
>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>
>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<
.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>
>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<
<..>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<
<<<<.....<<<....>>>...<.{{<<<<<<...<<<<.<<<<<<<.<<
<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<...
..>>>....>>>>>>.....>>>>>....><<<<<<<...>>>>>>>>>>
>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>
>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>
>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.......
........>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>.....
.......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<
.....>>>>......>>>>>>>.............<<<.<<..<<<....
.<<<<....>>>>.....>>>>>>>>........<<.<......>.>>..
........<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>
>>>....>>....<<<<<....>>>>>....<<<<<..<<<<......<<
<<<<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<...>>>>>>>>>>
...<<<<<.....<<<<...<<<<.....>>>>...........}}...<
<<<<<..>>>>>>..>>>>.>>>>>.....>>>>>>>>..>>>>>.....
.<..<...<<<<<<..........>>>>>>.......<<<<<<<...<<<
<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<..
<<<<.......>>>>..>>>.<<<....>>>...>.>......<<<<<..
.<<<<.))))))>>>>.>>>>>.........>>>>..>>>>>>>......
.......<<<<<<...<<.....>>...>>>>>>................
<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.......
..>>>.....>>>>....>>>>......<<<<<<<....>>>.>>>>...
.>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<..........
.....>>>>>>.><<<<<...<<<<...<<<<<<<<<<<]]].>>>>>..
>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>..
.>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<<....<<....
......<<<<<<.....>>>>>>......>>.......<<<<<<...<<<
<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.
>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<
<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>
>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oh3 Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): G16 I19 S34 K35 K38 Q42 R44 K50 W51 K53 R56 K61 E62 R111 M112 N115 R122
• Binding residue (residue number reindexed from 1): G16 I19 S34 K35 K38 Q42 R44 K50 W51 K53 R56 K61 E62 R111 M112 N115 R122

Gene Ontology

Molecular Function

• GO:0001671 ATPase activator activity
• GO:0051117 ATPase binding

Biological Process

• GO:0032781 positive regulation of ATP-dependent activity
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0030687 preribosome, large subunit precursor

External links

• PDB: RCSB:7oh3, PDBe:7oh3, PDBj:7oh3
• PDBsum: 7oh3
• PubMed: 34813592
• UniProt: Q07915|RLP24_YEAST Ribosome biogenesis protein RLP24 (Gene Name=RLP24)