Structure of PDB 7of3 Chain u Binding Site BS01

Receptor Information

>7of3 Chain u (length=111) Species: 9606 (Homo sapiens)

KFDIDMMVSLLRQENARDICVIQVPPEMRYTDYFVIVSGTSTRHLHAMAF
YVVKMYKHLKCKRDPHVKIEGKDTDDWLCVDFGSMVIHLMLPETREIYEL
EKLWTLRSYDD

Ligand information

>7of3 Chain A (length=1386)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacccaaauaaaguauaggcgauagaaauugaaauggcgcaauag
auauaguaccgcaagggaaagaugaaaaacaagcauaauauagcaaggac
uaaccccuauaccuucugcaaugaauuaacuagaaauaacuuugcaagga
gagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcua
aaagagcacacccgucuauguagcaaaauagugggaagauuuauagguag
aggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaau
cuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccuuccuuaaauaggga
uggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugac
cugcccgugagaggcgggcauaacacagcaagacgagagacccuauggag
cuuuaauuuauuaaugcaaacaaccugcauuaaaaauuucgguuggggcg
accucggagcagaacccaaccuccgagcaguacaugcuaagacuucacca
gucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguua
cccuagggaaauccuauucuagaguccauaucaacaauaggguuuacgac
cucguuggaucaggacaucccgauggugcagccgcuauuaaagguucguu
uguucaacgauuaaaguccuacgugaucugaguucagaccggaguaaucc
aggucgguuucuaucuacuuuaauuccucccuguacgaaaggacaagaga
aauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucuca
acuuaguauuauacccacacacccaagaacaggguu

<<<.......<<<<.................................<..
....>...............<<.....>>...........>>.>>.....
........<<....>>...............>>>...........<<<..
.....>>>...<.<<....>>.>.<<<<<<.........<<<.<<..<<.
...>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.
....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>..
.<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<
....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<....[.>>>>>>>>>>...<<<......>>>
....<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<.<<<<.....>>>>.
.>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.........
..<<<<<.......>>>>>.......<<..<<<.<<<...<<<<<.<<<<
<<..<<<<<.<<<<<<<<.......>>>>>>>>>>>>>..<<<<((((.>
>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>
>>>..>>>....>>.........<<<....>>>............>>>>.
.>>>>>>>.<<<<<<<<<...<<.......>>...>>>>>>>>>]....)
))).<<<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<
.....>>>>>.....>>>>>......>>>>>.....<<<<<<<....>>>
.>>>>...>>>..>>>.>>...<<<.<<<.................>>>.
>>><<<<<...<<<....>>>.>>>>>......<<<..............
..>>>...............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of3 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): K144 K147 H156
• Binding residue (residue number reindexed from 1): K54 K57 H66

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0043023 ribosomal large subunit binding
• GO:0140978 mitochondrial large ribosomal subunit binding

Biological Process

• GO:0017148 negative regulation of translation
• GO:0042254 ribosome biogenesis
• GO:0042273 ribosomal large subunit biogenesis
• GO:0070130 negative regulation of mitochondrial translation
• GO:0090071 negative regulation of ribosome biogenesis

Cellular Component

• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix
• GO:0005829 cytosol

External links

• PDB: RCSB:7of3, PDBe:7of3, PDBj:7of3
• PDBsum: 7of3
• PubMed: 34135319
• UniProt: Q96EH3|MASU1_HUMAN Mitochondrial assembly of ribosomal large subunit protein 1 (Gene Name=MALSU1)