Structure of PDB 6spf Chain u Binding Site BS01

Receptor Information

>6spf Chain u (length=34) Species: 287 (Pseudomonas aeruginosa)

SREFYEKPTAERRRKAAAAVKRHAKKVQREQRRR

Ligand information

>6spf Chain a (length=1390)

gaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacaca
ugcaagucgagcggaugaagggagcuugcuccuggauucagcggcagacg
ggugaguaaugccuaggaaucugccugguagugggggauaacguccggaa
acgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucg
gaccucacgcuaucagaugagccuaggucggauuagcuaguugguggggu
aaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagu
cacacuggaacugagacacgguccagacuccuacgggaggcagcaguggg
gaauauuggacaaugggcgaaagccugauccagccaugccgcgugucuuu
aaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuacc
aacagaauaagcaccggcuaacuucgugccagcagccgcgguaauacgaa
gggugcaagcguuaaucggaauuacugggcguaaagcgcgcguagguggu
ucagcaaguuggaugugaaauccccgggcucaaccugggaacugcaucca
aaacuacugagcuagaguacgguagagggugguggaauuuccuggaagga
acaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcg
aaagcguggggagcaaacaggauuagauacccugguaguccacgccguaa
acgaugucgacuagccguugggauccuugagaucuuaguggcgcagcuaa
cgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaa
ugaauugacgggggcccgcacaaugcugagaacuuuccagagauggauug
gugccuucgggaacucagacacaggugcugcauggccagcucgugucgug
agauguuggguuaagucccguaacgagcgcaaccuccuuaguuaccagca
ccucgggugggcacucuaaggagacugccggugacaaaccggaggaaggu
gucaagucaucauggcccuuacggccagggcuacacacgugcuacaaugg
ucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaacc
gaucguaguccggaucgcagucugcaacucgacugcgugaagucggaauc
gcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuug
uacacaccgcccgucacaccaugggaguggguugcuccagaaguagcuag
ucuaaccgcaagggggacgguuaccacggagugauucaugacugggguga
agucguaacaagguagccguaggggaaccugcggcuggau

...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.
<<<..<<<..<<.<<<...<..<<<..>>>..>..>.>>.>>>>>.....
.<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<...
.>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....
>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<<..
.....>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>
.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>..
.......<<<....<<<<....>>>>..>>>..>>.>>>>>>........
..<<<<<......<<<..<..<<........>>..>..>>>.......>>
>>>.......<<<<<((.....<<<<.....<<..))>>.......>>>>
.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<
<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>
>..>>.>>>>>>...<<<<<<<....<<<<<<<.....<<<<.>>>>...
.........<<....>>.>>>>>>>...>>>.>>>>...>>>...>>>>.
...<<<<<<<...<...<<<<.........>>>>...>>>>>>>>.....
.....<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..)
)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)
))).]<<<<<.<<<<<<<.<<....<<<.........<.......>....
...<......>....>>>.........<..........<<<<<<<<<...
.>>>..<<<<......>>>>..>>>>>>....................<<
.......>>..................<<<<<.....>>>>>........
.............>....................................
..................................................
..................................................
....................................>>...>>>>>>>>>
>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<
<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>.
.>.>>...>.....<<<<<<<<<....>>>>>>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6spf Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): R35 K40 P41 T42 R46 A52 R55
• Binding residue (residue number reindexed from 1): R2 K7 P8 T9 R13 A19 R22

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6spf, PDBe:6spf, PDBj:6spf
• PDBsum: 6spf
• PubMed: 31611393
• UniProt: A0A069QC99