Structure of PDB 6gqb Chain u Binding Site BS01

Receptor Information
>6gqb Chain u (length=260) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARGPKKHLKRLAAPHHWLLDKLSGCYAPRPSAGPHKLRESLPLIVFLRNR
LKYALNGREVKAILMQRHVKVDGKVRTDTTYPAGFMDVITLDATNENFRL
VYDVKGRFAVHRITDEEASYKLGKVKKVQLGKKGVPYVVTHDGRTIRYPD
PNIKVNDTVKIDLASGKITDFIKFDAGKLVYVTGGRNLGRIGTIVHKERH
DGGFDLVHIKDSLDNTFVTRLNNVFVIGEQGKPYISLPKGKGIKLSIAEE
RDRRRAQQGL
Ligand information
>6gqb Chain 2 (length=1776) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagucc
uuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguu
caaagcaggcguauugcucgaauauauuagcauggaauaauagaauagga
cguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagg
gacggucgggggcaucaguauucaauugucagaggugaaauucuuggauu
uauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaa
ucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucu
uaaccauaaacuaugccgacuagggaucgggugguguuuaugacccacuc
ggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucg
caaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggag
ccugcggcuuaauuugacucaacacggggaaacucaccagguccagacac
aauaaggauugacagauugagagcucuuucuugauuuugugggugguggu
gcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaa
cgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuau
ccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaa
uaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacac
ugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugu
gaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacg
aggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccug
cccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugag
gccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaa
uuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuc
cguaggugaaccugcggaaggaucau
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..................<<....<<
.<<.......>>.>>.....>>.........<<<<<............>>
>>>....<<<<<<......(((((((.<<<....>>>.............
.>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>
>>>>>.>>>......<<..<...........>..>>.........<<<<<
((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<.......<.<<...<<<.<<....<<<<<<.<<<
<<............>>>>>.>>>>>>.....<<<<<........<<<...
......>>>........>>>>>....<<<<<.<<.......<<...<...
....>..<<<.....>>>....>>......>>.>>..>>>.........<
<...<<<<<<<<.....))))))).>>>>>>>>..>>.....>>....<<
<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>
.>>>>>.>.>>.......<<....>>...>>>>..>.>>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<.<<<...>>>>>>>>>
>>..>>>...<<....>>...>>.....>>>.>>>.<<<......<<<<.
...>>>>....>>>..]]]].}<<<<<.<<<<<<<....<.<<<<<.<<<
<.<<<<<<......<<........>>..........<<<<<......<<<
<<........<..<<<........>>>.>.......>>>>>.........
.....<<<<<<....<<<.<<<<......>>...<<<......>>>...>
>.>>>....<<<<<.<<.....<..<<<<<..<.<<<....>>>>.....
>>>>>..>....>>....<<<<<<.....>>>>>>.......>>>>>...
.>>>.>>>...................>>>>>...>>.>>>>.>>>.>..
.<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>...
....>>>>>>>......<....<<<<<<..........>>>>>>....>.
....>>>>>......<<<<<<<.......>>>>>>>.......>....>>
>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<
.<<..<...<<<<<<<.<<..................>>.>>>>>>>...
>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<
<<<<<<<..>>>>>>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6gqb Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
Resolution3.9 Å
Binding residue
(original residue number in PDB)
R3 P5 K6 K7 H8 K10 L12 L19 D21 K22 L23 C26 Y27 A28 P29 A33 G34 P35 H36 K37 L38 R39 R49 R51 N57 G58 R59 M66 R108 K128 Q130 L131 G132 K133 K134 G135 Y138 V140 T146 R148 R187 H197 K198 R200 G203 R221 I248 Q258
Binding residue
(residue number reindexed from 1)
R2 P4 K5 K6 H7 K9 L11 L18 D20 K21 L22 C25 Y26 A27 P28 A32 G33 P34 H35 K36 L37 R38 R48 R50 N56 G57 R58 M65 R107 K127 Q129 L130 G131 K132 K133 G134 Y137 V139 T145 R147 R186 H196 K197 R199 G202 R220 I247 Q257
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0032991 protein-containing complex
GO:0043232 intracellular non-membrane-bounded organelle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6gqb, PDBe:6gqb, PDBj:6gqb
PDBsum6gqb
PubMed29886014
UniProtP0CX35|RS4A_YEAST Small ribosomal subunit protein eS4A (Gene Name=RPS4A)

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