Structure of PDB 8esq Chain t Binding Site BS01

Receptor Information

>8esq Chain t (length=235) Species: 4896 (Schizosaccharomyces pombe)

PEVLLKKRKVNERTRKERVEQAIAKKEAQKKNRKETFKRAETFINNYRQR
ERERIRLNRSAKNKGDIFVPDETKLLFVIRIAGVKNMPPKIRKVLRLLRL
SRINNAVFVRNNKAVAQMLRIVEPYVMYGIPNLHSVRELIYKRGFGKING
QRIALSDNALIEEALGKYDVISIEDIIHEIYNVGSHFKEVTKFLWPFTLT
PVKHSLMEKKVKHFNEGRKAGYCGEEINELIKKQV

Ligand information

>8esq Chain 1 (length=2230)

uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaau
uugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaag
cugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucag
agagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgc
uuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagc
uaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaug
aaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaaggg
aagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaaua
agggaagguggcuguuuauagcccuuguuguaauacguccacuggggacu
gaggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccg
ucuugaaacacggaccaaggagucuagcaucuaugcgaguguuuggguga
ugaaaacccauccgcgaaauggugaaugcaggugggaacgcccuuguggc
gugcaccaucgaccgguaagagcauagcuguugggacccgaaagauggug
aacuaugccugaauagggugaagccagaggaaacucugguggaggcucgu
uuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccug
ccgaaguuuccggauagcagaaacucagaucaguuuuaugaguauguaaa
augagaguuucuagugggccauuuuugguaagcagaacuggcgaugcggg
augaaccgaacgugagguuaaggugccggaauguacgcucaucagacgaa
aagguguuaguucaucuagacagcaggacgguggccauggaagucggaau
ccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaa
auggauggcgcuuaagcguacuacccauaccucaccgucuggguuagcuu
ugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuug
ggcgugagccugggucgaacagccucuagugcagaucuugguggaaguag
cauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaa
cagcaguuggacauggguuagucgauccuaagagauagggaagcuccgua
ugaaaggcacgauuuuucgugccuaucgaaagggaauccgguuaauauuc
cggaaccagaagguggaaucaacacggcaacguaaaugaaguuggagacg
ucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccacacc
cugaaaucgguuuauccggagcuaggguaugguguuuggaagaguucagc
gaugcugaauccggugcgcucucgacggcccuugaaaauccaacggaagu
uguuuucacaucuggucguacuccuccaaggugccucuaguugauagaac
aauguagauaagggaagucggcaaaaugggaauucccacugucccuaucu
acuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcgg
cccuguugagcuugacucuaguuugacauuugucagguggggaguuaaag
uuaccacagggaucuuguggcagccaagcgcgacguugcuucggcucuuc
cuaucauaccgaagcagaauucgguaagcguuggacccacuaauagggaa
cgugagcugggaccgucgugagacgguuaguccuacugaugaagugucgu
cgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauu
gguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccg
gauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgau
uauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggc
gaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccau
gaauccauugcauacgacuuuaauguggaacgggguauuguaagcagcug
cugagauuaagccuuuguucccaagauuug

........................<<<<<<........>>>>>.>.....
....<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.
......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<
<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((...
...<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>
>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>
..................................<<....>>........
.......<<<<....>>>>...............................
...<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<
<<<<......<...>......>>>>>>>>......>>>>>.>>>>>>>>>
>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<
<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<..
.....>>>>...>>>...<<.>>.......<<<<<..<<<<<.....>>>
>>...>>>>>.<<..>>....>>>>>>.>>>>>>..<<.<...<<<<<<.
..<<<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>.>
>>>>>>>>>><<.<....>.>>......>>>>>>......>.>>..<<<<
<<....<.<<..>>.><<<<<<<<<<...<<<.<<<<<<<....>>>>>>
>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<.
.....>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.....
.<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>...
.>>.........<<......>>...>>>>>...>>>>>>>>>>>>>....
......))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<......
......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<
<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<
<.<<<<<<.......>>>>>><<<<.....<<<<..<<...<<<<<<...
..........>>>>>>....((<<<<<<...<<....<<<....>>>...
.....<<<<<<......>>>>>>..>>....>>...<<<<<........>
>>>>))<<<<..<<<<<<<....<<<....>>>.......<<<<<<...<
<<<.<<<<<<<<<<<<<<<<<<...((..>>>>>>....<<<<<...<<<
<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<
<.>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>......
.>>>>.>>>.>>>>>>>>..>>.>>>>.<<<..>>>..>>>>..<<<<..
...<<<<<<<.<<.........<....<<<<<>>>>>..>..>>.>>>>>
>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<.<<
<<<<<.<<<<<<<<<<<<<.<<<<<<<<..>>>>>>>>..>>>>>>.>>>
>>..>>>>>>>........<<<<<...<..>...>>>>>..<<<<...<<
<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>..
.....>>>>.<<<<<<<....>>>>>>>....>>.>>>>>.....<<<<<
<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<
<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<
<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>
.....<<.......<<<<..<..>..>>>>....>>........<<<<<.
...<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........
<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>
>...>>>....>>>>.>>>>>...>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8esq Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): V24 E26 R27 R29 R32 K224
• Binding residue (residue number reindexed from 1): V10 E12 R13 R15 R18 K210

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0030687 preribosome, large subunit precursor
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8esq, PDBe:8esq, PDBj:8esq
• PDBsum: 8esq
• PubMed: 36423630
• UniProt: P17937|RL7A_SCHPO Large ribosomal subunit protein uL30A (Gene Name=rlp7)