Structure of PDB 7qp6 Chain t Binding Site BS01

Receptor Information
>7qp6 Chain t (length=356) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGY
ANAKIHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEH
LAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP
ISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSVAGGSILKGVLK
VGQEIEVRPGIVSKKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKI
DPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRKLSKNEVL
MVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLI
GWGQIR
Ligand information
>7qp6 Chain w (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgau
ggaucgaaaccauccucugcuacca
.<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>.>>>>>.....
Receptor-Ligand Complex Structure
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PDB7qp6 Conformational rearrangements upon start codon recognition in human 48S translation initiation complex.
Resolution4.7 Å
Binding residue
(original residue number in PDB)		R68 K70 S261 V278 E324 H325 R349
Binding residue
(residue number reindexed from 1)		R35 K37 S188 V189 E231 H232 R256
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, RNA binding
GO:0016787 hydrolase activity
GO:0045296 cadherin binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qp6, PDBe:7qp6, PDBj:7qp6
PDBsum7qp6
PubMed35489072
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

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