Structure of PDB 7o9k Chain t Binding Site BS01

Receptor Information

>7o9k Chain t (length=381) Species: 9606 (Homo sapiens)

KPHVNVGTIGHVDHGKTTLTAAITKILAEGGGAKFKKYEEIDNAPEERAR
GITINAAHVEYSTAARHYAHTDCPGHADYVKNMITGTAPLDGCILVVAAN
DGPMPQTREHLLLARQIGVEHVVVYVNKADEMVELVELEIRELLTEFGYK
GEETPVIVGSALCALEGRDPELGLKSVQKLLDAVDTYIPVPARDLEKPFL
LPVEAVYSVPGRGTVVTGTLERGILKKGDECELLGHSKNIRTVVTGIEMF
HKSLERAEAGDNLGALVRGLKREDLRRGLVMVKPGSIKPHQKVEAQVYIL
SKEEGGRHKPFVSHFMPVMFSLTWDMACRIILPPEKELAMPGEDLKFNLI
LRQPMILEKGQRFTLRDGNRTIGTGLVTNTL

Ligand information

>7o9k Chain A (length=1436)

gcuaaaccuagccccaaacccacuccaccuuacuaccacaaccuuagcca
aaccauuuacccaaauaaaguauaggcgauagaaauugggcgcaauagau
auaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggac
uaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaag
gagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagc
uaaaagagcacacccgucuauguagcaaaauagugggaagauuuauaggu
agaggcgacaaaccuaccgagccuggugauagcugguuguccaagauaga
aucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuugu
aaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaa
aaccuuguagagagaguaaaaaauuuaacccauaguaggccuaaaagcag
ccaccaauuaagaaagcguucaagcucaaaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gaucacugaacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaag
guuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuacca
aaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagug
aucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguuc
agcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcg
ggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaau
gcaaacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacc
caaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccuca
auugauccaauaacuugaccaacggaacaaguuacccuagggauaacagc
gcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgaug
uuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguu
caacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggu
cgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaa
uaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaac
uuaguauuauacccacacccacccaagaacaggguu

<<<.......<<<<...................................<
......>.........<.....<<.....>>....>..>>.>>.......
......<<....>>.................>>>...........<<<..
.....>>>...<.<<......>>.>.<<<<<<.........<<<.<<..<
<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<
<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>
...<<.......>>......>.>>>>......>.>>..<<<<<<....<<
<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>
>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<....
..>>>....<<<.<<<...<............<....<<<.........>
>>....>.......<<<......>>>.......................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<.........>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<......>>.>>>>.....>>>>..<
<<<...<<<<<<<<.<<.........<......<<<<<<..<<<......
...>>>...<<<<<<.............>>>>>>....<<<.....<<<<
..>>>>.<<<<<<.....>>>>>>..........>>>....>>.>>>>..
...>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>
>>>.......<<..<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<<<
<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<........
.....>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>..
.......<<<....>>>............>>>>..>>>>>>>.....<<<
<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.>....<
<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<....
.>>>>>.....>>>>>..>...>>>.>>>...<<<<<<<....>>>.>>>
>....>>..>>>.>>.....<<<.<<<.................>>>.>>
><<<<<...<<<....>>>.>>>>>......<<<................
>>>.................<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o9k Structural basis for late maturation steps of the human mitoribosomal large subunit.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K368 R429
• Binding residue (residue number reindexed from 1): K309 R370

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005515 protein binding
• GO:0005525 GTP binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0045471 response to ethanol
• GO:0070125 mitochondrial translational elongation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005741 mitochondrial outer membrane
• GO:0016020 membrane
• GO:0042645 mitochondrial nucleoid
• GO:0045202 synapse
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7o9k, PDBe:7o9k, PDBj:7o9k
• PDBsum: 7o9k
• PubMed: 34135318
• UniProt: P49411|EFTU_HUMAN Elongation factor Tu, mitochondrial (Gene Name=TUFM)