Structure of PDB 6zmw Chain t Binding Site BS01

Receptor Information
>6zmw Chain t (length=356) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGY
ANAKIHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEH
LAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIP
ISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSVAGGSILKGVLK
VGQEIEVRPGIVSKKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKI
DPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRKLSKNEVL
MVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLI
GWGQIR
Ligand information
>6zmw Chain w (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgau
ggaucgaaaccauccucugcuacca
<<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<
<<.......>>>>>.>>>>>>....
Receptor-Ligand Complex Structure
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PDB6zmw Structure of a human 48Stranslational initiation complex.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R68 S261 R349
Binding residue
(residue number reindexed from 1)		R35 S188 R256
Enzymatic activity
Enzyme Commision number 3.6.5.3: protein-synthesizing GTPase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008135 translation factor activity, RNA binding
GO:0016787 hydrolase activity
GO:0045296 cadherin binding
GO:1990856 methionyl-initiator methionine tRNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zmw, PDBe:6zmw, PDBj:6zmw
PDBsum6zmw
PubMed32883864
UniProtP41091|IF2G_HUMAN Eukaryotic translation initiation factor 2 subunit 3 (Gene Name=EIF2S3)

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