Structure of PDB 6v6s Chain t Binding Site BS01

Receptor Information
>6v6s Chain t (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
REIITLQLGQCGNQIGFEFWKQLCAEHGISPEAIVEEFTDRKDVFFYQYI
PRAVLLRVIHSILNSPYAKLYGNNWASGFSQGEKIHEDIFDIIDREADGS
DSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPVQPYNS
LLTLKRLTQNADCLVVLDNTALNRIATDRLHIQSFSQINQLVSTIMSAST
TTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTVLDVMRRLLQPK
NVMVSNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQV
ALSRKSPYLRVSGLMMANHTSISSLFERTCRQYDKLRKREDNFDEMDTSR
EIVQQLIDEYHAATRPDYIS
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain6v6s Chain t Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6v6s Asymmetric Molecular Architecture of the Human gamma-Tubulin Ring Complex.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		C13 G144 T145
Binding residue
(residue number reindexed from 1)		C11 G115 T116
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0007020 microtubule nucleation
GO:0007052 mitotic spindle organization
GO:0031122 cytoplasmic microtubule organization
Cellular Component
GO:0000242 pericentriolar material
GO:0000794 condensed nuclear chromosome
GO:0000930 gamma-tubulin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005827 polar microtubule
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0005929 cilium
GO:0015630 microtubule cytoskeleton
GO:0031252 cell leading edge
GO:0036064 ciliary basal body
GO:0043005 neuron projection
GO:0045177 apical part of cell
GO:0055037 recycling endosome
GO:0097730 non-motile cilium
GO:1990498 mitotic spindle microtubule

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6v6s, PDBe:6v6s, PDBj:6v6s
PDBsum6v6s
PubMed31862189
UniProtP23258|TBG1_HUMAN Tubulin gamma-1 chain (Gene Name=TUBG1)

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