Structure of PDB 8gzu Chain sb Binding Site BS01

Receptor Information
>8gzu Chain sb (length=279) Species: 312017 (Tetrahymena thermophila SB210) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SICLESISGTIKGLQKANYVVEHNPNLTSEEKKHLKQFLVYRYNPADPHD
QPKYVSYWCDIKKFPPMFLDAILYIKNELDPTLSIRRSCREGICGSCAVN
CDGLHTLACISGFNRDLSKPTIITPLGHMFILKDLVVDMTNFYAQYKMIE
PYLKRKTPKPDANKEYPQSPEQRALLDGLYECVLCAACSTSCPSYWWHPD
RYLGPAILQQAYRWIVDSRDEYTQERIERIAEDVRLDDCQQIGMCSFTCP
KGLNPQLSLKNLMDMVKDFRQKRIEQEVL
Ligand information
Ligand IDFES
InChIInChI=1S/2Fe.2S
InChIKeyNIXDOXVAJZFRNF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04[Fe]1S[Fe]S1
CACTVS 3.341
OpenEye OEToolkits 1.5.0		S1[Fe]S[Fe]1
FormulaFe2 S2
NameFE2/S2 (INORGANIC) CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8gzu Chain sb Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8gzu Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		R120 C122 R123 G125 C127 G128 S129 C130 L140 C142
Binding residue
(residue number reindexed from 1)		R87 C89 R90 G92 C94 G95 S96 C97 L107 C109
Annotation score1
Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Gene Ontology
Molecular Function
GO:0008177 succinate dehydrogenase (quinone) activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
Cellular Component
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gzu, PDBe:8gzu, PDBj:8gzu
PDBsum8gzu
PubMed37248254
UniProtI7M403

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