Structure of PDB 8gzu Chain s8 Binding Site BS01

Receptor Information
>8gzu Chain s8 (length=218) Species: 312017 (Tetrahymena thermophila SB210) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GYIQRSNIHEEAPNTSVEAKHHNKTFYDPILDIDEDLKDDIRLYGRDKPD
ELDFTDVWESSYQNIICPEYFYHFWFCGIVYSFEPEWTINYPFEKGPLSP
LFRGEHALRRYPTGEERCIACKLCQSACPARAITIETEPRPDGSRRTVRY
DIDMTKCIYCGFCQEACPVDAIVEGPNYEQTAYLHEDLFYDKYKLLENGD
KWEPQIARNIEYLINQPL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8gzu Chain s8 Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8gzu Structures of Tetrahymena thermophila respiratory megacomplexes on the tubular mitochondrial cristae.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		C146 C175 I176 Y177 C178 G179 F180 C181
Binding residue
(residue number reindexed from 1)		C128 C157 I158 Y159 C160 G161 F162 C163
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0032981 mitochondrial respiratory chain complex I assembly
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gzu, PDBe:8gzu, PDBj:8gzu
PDBsum8gzu
PubMed37248254
UniProtI7MDW5

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