Structure of PDB 5dat Chain s8 Binding Site BS01

Receptor Information
>5dat Chain s8 (length=188) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHSVRTRGG
NKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAI
VQIDATPFRQWFEAHYGQTLGKKSKNAERKWAARAASAKIESSVESQFSA
GRLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK
Ligand information
>5dat Chain 6 (length=1795) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugug
guaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagau
guauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucaua
auaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauu
ucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaa
cggguaacggggaauaaggguucgauuccggagagggagccugagaaacg
gcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaau
ucagggagguagugacaauaaauaacgauacagggcccauucgggucuug
uaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggaggg
caagucuggugccagcagccgcgguaauuccagcuccaauagcguauauu
aaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggc
cgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcu
aaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaa
aauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaau
aauagaauaggacguuugguucuauuuuguugguuucuaggaccaucgua
augauuaauagggacggucgggggcaucaguauucaauugucagagguga
aauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaagga
cguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagaua
ccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguu
uuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguuc
uggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaaggg
caccaccaggaguggagccugcggcuuaauuugacucaacacggggaaac
ucaccagguccagacacaauaaggauugacagauugagagcucuuucuug
auuuugugggugguggugcauggccguucuuaguugguggagugauuugu
cugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugc
uagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccg
auggaaguuugaggcaauaacaggucugugaugcccuuagacguucuggg
ccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgaga
ggucuugguaaucuugugaaacuccgucgugcuggggauagagcauugua
auuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuug
cguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccga
uugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuc
caucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaa
agucguaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[..<<....<<....<<..........>>...>>.>>......{{..
......[[[..{{..{{....[[[...............<.....<<.<<
.......>>.>>......>.........<<<<<..<......>..>>>>>
....((((((......<<<<<<<<<<<<..>>>>..............))
)))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}.
.]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>.....
.>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........
>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<...
..>>>..>>>...............<<<<<<<<.<..........>.>>>
>>.>>>......<<..<...........>..>>.........<<<<<((.
.....<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]
].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<
<<<...............>>>>......>>>.>>>>>>....<<<<<<..
..<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<....
...<<...<.......>..<<<.....>>>....>>......>>.>>..>
>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].
....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<....
..>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>
>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>
.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<
........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]
]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<
<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.......
...<<<<<......<<<<<........<<.<<<........>>>.>>...
...>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>..
.<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<
<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>
>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>.
..>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....
>>>>..>>....>>.......>>>>>>>...........<<<<<<.....
.....>>>>>>..........>>>>>>....<<<<<<<<.......>>>>
>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<..
..<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<<.......>>
...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>..
.>.>>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5dat Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome
Resolution3.15 Å
Binding residue
(original residue number in PDB)
G2 I3 R5 D6 H9 K10 R11 A13 T14 G15 A16 K17 R18 F21 R22 K23 K24 R25 K26 F27 L29 G30 R31 Q32 P33 A34 K41 R42 I43 H44 R47 T48 R49 G50 G51 K54 R56 R59 N64 G71 I72 S73 K75 S86 N87 T97 K98 K137 N138 R141 K142 A145 R146 S170 S171 R172 G174 Q175 S176 R178 D180
Binding residue
(residue number reindexed from 1)
G1 I2 R4 D5 H8 K9 R10 A12 T13 G14 A15 K16 R17 F20 R21 K22 K23 R24 K25 F26 L28 G29 R30 Q31 P32 A33 K40 R41 I42 H43 R46 T47 R48 G49 G50 K53 R55 R58 N63 G70 I71 S72 K74 S85 N86 T96 K97 K125 N126 R129 K130 A133 R134 S158 S159 R160 G162 Q163 S164 R166 D168
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:5dat, PDBe:5dat, PDBj:5dat
PDBsum5dat
PubMed
UniProtP0CX39|RS8A_YEAST Small ribosomal subunit protein eS8A (Gene Name=RPS8A)

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